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| Status |
Public on Dec 22, 2023 |
| Title |
HiCAR analysis of zebrafish fin regeneration identifies cis-regulatory chromatin reorganization in response to injury |
| Organism |
Danio rerio |
| Experiment type |
Other
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| Summary |
HiCAR (Hi-C on accessible regulatory DNA), which is a genome-wide profiling of chromatin accessibility and open chromatin anchored cis-regulatory element (cRE) interactions, identified 28690 calling loops from zebrafish caudal fins at three different time points (0, 1 and 4 day(s) post amputation (dpa)) including 5022 regeneration-responsive loops (17.5%).
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| Overall design |
10 caudal fins each of adult wild type zebrafish at 0, 1 and 4 dpa time points were pooled and three biological replicates were used for preparing HiCAR DNA libraries 10 caudal fins each of adult wild type zebrafish at 0, 1 and 4 dpa time points were pooled and three biological replicates were used for preparing HiCAR DNA libraries to find regeneration-responsive loops only in 1 and/or 4 dpa regenerating fins not in 0 dpa uninjured control fins..
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| Contributor(s) |
Poss KD, Ando K, Ou J, Diao Y, Wei X |
| Citation(s) |
38290519 |
| Submission date |
May 05, 2023 |
| Last update date |
Mar 22, 2024 |
| Contact name |
jianhong ou |
| E-mail(s) |
jianhong.ou@duke.edu
|
| Phone |
5084102796
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| Organization name |
Duke University
|
| Department |
Cell Biology
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| Lab |
Regeneromics
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| Street address |
465 Nanaline Duke Building, Duke University Medical Center
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| City |
Durham |
| State/province |
North Carolina |
| ZIP/Postal code |
27710 |
| Country |
USA |
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| Platforms (1) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA967663 |
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