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Series GSE201032 Query DataSets for GSE201032
Status Public on Jul 31, 2023
Title Sex shapes cell-type-specific transcriptional signatures of stress exposure in the mouse hypothalamus
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Stress-related psychiatric disorders and the stress system show prominent differences between men and women. These sex differences are detectable at the transcriptional level but we lack cell-type specific information. Here, using single-cell transcriptomics, we identify cell-type-specific signatures of acute restraint stress in the paraventricular nucleus of the hypothalamus - a central hub of the stress response - in male and female mice. Further, we show that a history of chronic mild stress alters these acute stress signatures in a sex-specific way. Using this dataset, we identified oligodendrocytes as a major target for sex-specific effects of stress. This dataset provides the first molecular resource for an in-depth dissection of the interplay between cell types and sex on the mechanisms of the stress response, offering the transcriptomes of thousands of individual cells.
Overall design Single-cell RNA-sequencing of male and female mice without (controls) or after stress exposure (acute restraint stress (ARS) or acute restraint stress after chronic mild stress (CMS ARS))
Web link
Contributor(s) Brivio E, Lopez J, Chen A
Citation(s) 37516966
Submission date Apr 19, 2022
Last update date Aug 01, 2023
Contact name Alon Chen
Organization name Weizmann Institute of Science
Department Brain Sciences
Street address Arison Neurobiology Building
City Rehovot
ZIP/Postal code 76100
Country Israel
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (8)
GSM6049315 F_baseline_ctrl
GSM6049316 M_baseline_ctrl
GSM6049317 F_baseline_ARS
BioProject PRJNA828111

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE201032_Metadata.csv.gz 1.7 Mb (ftp)(http) CSV
GSE201032_RAW.tar 252.8 Mb (http)(custom) TAR (of TAR)
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Raw data are available in SRA
Processed data provided as supplementary file

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