 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Apr 30, 2024 |
| Title |
Acute social isolation alters synaptic plasticity in lateral habenula and social decision |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The lateral habenula (LHb) is an essential hub brain region modulating the monoamine system such as dopamine, serotonin. Hyperactivity of LHb has implications for psychiatric disorders such as depression, anxiety, and schizophrenia, which are commonly associated with social dysfunction. However, the role of LHb in social behavior has remained elusive. Here, we find that experiencing acute social isolation affects synaptic function in LHb and social behavior. After acute social isolation, long-term depression (LTD) in LHb is impaired and rescued by activating the 5-HT4 receptor (5-HT4R). Indeed, Htr4 expression in LHb is up-regulated following acute social isolation. Finally, acute social isolation enhances the social preference for familiars such as housing-mates to stranger conspecifics. Consistent with electrophysiological results, pharmacological activation of 5-HT4R in LHb restored innate social preference. These results suggest that acute social isolation influences social decisions with 5-HT4R-dependent synaptic modification in LHb.
|
| |
|
| Overall design |
The transcriptomic profiles of lateral habenula tissues obtained from group-housed and socially isolated mice
|
| |
|
| Contributor(s) |
Kim J, Chae S, Kang M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 03, 2022 |
| Last update date |
Apr 30, 2024 |
| Contact name |
Sehyun Chae |
| E-mail(s) |
shchae@kbri.re.kr
|
| Organization name |
Korea Brain Research Institute
|
| Department |
Neurovascular Unit Research Group
|
| Street address |
61, Cheomdan-ro, Dong-gu
|
| City |
Daegu |
| ZIP/Postal code |
41062 |
| Country |
South Korea |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA822836 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE200082_RAW.tar |
1000.0 Kb |
(http)(custom) |
TAR (of TXT) |
| GSE200082_Raw_counts_matrix.txt.gz |
332.8 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
| Processed data are available on Series record |
|
|
|
|
 |
Less...
More...