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| Status |
Public on Apr 06, 2022 |
| Title |
snoRNA sequencing of sEV isolated from plasma of astronauts |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
This study aimed to determine whether the spaceflight-induced snoRNA changes in plasma extracellular vesicles (EV) and astronauts' peripheral blood mononuclear cells (PBMCs) can be utilized as potential biomarkers. Using unbiased small RNA sequencing, we evaluated the EV snoRNA changes in peripheral blood (PB) plasma of astronauts (n=5/group) who underwent median 12-day long Shuttle missions between 1998-2001. Using stringent cutoff (> log 2-fold change, FDR < 0.05), we detected 21 down-regulated snoRNAs and 9 upregulated in PB-EVs at three days after return (R+3) compared to ten days before launch (L-10). Our findings unveiled that spaceflight induced changes in EV and PBMCs snoRNA expression, thus suggesting snoRNAs may serve as novel biomarkers for monitoring astronauts' health.
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| Overall design |
Comparison of snoRNA expression from blood sEVs at 2 time points.
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| Contributor(s) |
Goukassian DA, Garikipati VN, Hadri L, Uchida S, Arakelyan A, Mills P, Coleman M, Evans A, Sebastian A, Brojakowska A, Bisserier M, Rajan KS, Rai AK |
| Citation(s) |
35811715 |
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| Submission date |
Apr 03, 2022 |
| Last update date |
Jul 12, 2022 |
| Contact name |
Arsen Arakelyan |
| E-mail(s) |
aarakelyan@sci.am
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| Organization name |
Institute of Molecular Biology NAS RA
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| Department |
Bioinformatics
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| Street address |
7 Hasratyan St.
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| City |
Yerevan |
| State/province |
Yerevan |
| ZIP/Postal code |
0014 |
| Country |
Armenia |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA822839 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE200079_snoRNA_RuvSeq_counts.csv.gz |
4.2 Kb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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