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| Status |
Public on May 01, 2022 |
| Title |
Towards an Understanding of the Pathomechanisms of Uterine Fibroids |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Uterine fibroids (UFs) are benign tumours affecting up to 80% of women of reproductive age. Although mutations in MED12 or HMGA2 account for the majority of UF occurrence, the processes by which these lead to UFs remain poorly understood. Here we present a comprehensive systems biology study, merging clinical, genetic, transcriptomic and proteomic information to better understand the patho-mechanisms underlying UF.
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| Overall design |
Tissues from uterine fibroid patients were collected from 137 donors undergoing hysterectomy, myomectomy or TCRF at the John Radcliffe Hospital, Oxford, in accordance with guidelines under the ENDOX study (09/H0604/58). This study was supported by a grant within the Oxford-Bayer collaboration.
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| Contributor(s) |
Wang CY, Cribbs A, Philpott M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Mar 31, 2022 |
| Last update date |
Jun 15, 2022 |
| Contact name |
Adam Cribbs |
| E-mail(s) |
adam.cribbs@ndorms.ox.ac.uk
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| Organization name |
University of Oxford
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| Street address |
Windmill Road, Oxford, OX3 7LD, UK
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| City |
Oxford |
| ZIP/Postal code |
OX3 7LD |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (136)
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| Relations |
| BioProject |
PRJNA821713 |
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