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| Status |
Public on Dec 22, 2022 |
| Title |
MicroRNA-592 inhibits the progression of breast cancer through targeting CYP20A1 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Previous studies have shown that miR-592 may play an important role in the development of various cancer types. However, the mechanism of miR-592 in breast cancer progression remains unclear. Functional analysis showed that overexpression of miR-592 significantly inhibited the cell proliferation, clonal formation, and migration and invasion of MCF-7 cells in vitro. RNA sequencing (RNA-seq) was then used to identify the significantly dysregulated genes and enriched pathways in response to miR-592 overexpression in MCF-7 cells.
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| Overall design |
MCF-7 cells transfected with miR-592 mimics were the treatment group, and MCF-7 cells transfected with mimics NC were used as controls. Experiments were performed in duplicate. Gene expression profiling analyses by high throughput sequencing were performed on mRNA samples isolated from the MCF-7 cells transfected with miR-592 mimics (592mic) and MCF-7 cells transfected with mimics NC(592micNC).
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| Contributor(s) |
He K, Pan R, Su J, Meng X |
| Citation missing |
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| |
| Submission date |
Sep 16, 2021 |
| Last update date |
Dec 22, 2022 |
| Contact name |
Kan He |
| E-mail(s) |
hekan@ahu.edu.cn
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| Phone |
13866152995
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| Organization name |
Anhui University
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| Department |
School of life sciences
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| Lab |
Center for Stem Cell and Translational Medicine
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| Street address |
111 Jiulong Road
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| City |
Hefei |
| ZIP/Postal code |
230039 |
| Country |
China |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA763812 |
| SRA |
SRP337397 |
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