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Series GSE150894 Query DataSets for GSE150894
Status Public on Dec 17, 2020
Title RNAseq in Pten enhancer wild-type or deleted mouse T-ALLs
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary C57BL6 mice harboring Pten enhancer (PE) conditional knockout NOTCH1-induced leukemias were treated with vehicle (control) or tamoxifen to induce isogenic deletion of PE. Here we report the gene expression profile of leukemic blasts obtained from the spleen from control- or tamoxifen-treated leukemic mice. GSEA analysis show a significant enrichment of Pten signature genes, consistent with a role of PE in regulating Pten expression.
Overall design RNAseq analysis of leukemic spleens in two genotypes and four or five samples per genotype.
Contributor(s) Tottone L, Singh A, Khiabanian H, Herranz D
Citation(s) 33458694
Submission date May 20, 2020
Last update date Mar 18, 2021
Contact name Daniel Herranz
Organization name Rutgers Cancer Institute of New Jersey
Street address 195 Little Albany Street
City New Brunswick
State/province New Jersey
ZIP/Postal code 08901
Country USA
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (9)
GSM4560340 Spleen, TMX1
GSM4560341 Spleen, TMX2
GSM4560342 Spleen, TMX4
BioProject PRJNA634002
SRA SRP262417

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Supplementary file Size Download File type/resource
GSE150894_DESeqNormalizedCounts_PtenEnhDel_vs_Control.csv.gz 1.3 Mb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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