|
| Status |
Public on Dec 17, 2020 |
| Title |
RNAseq in Pten enhancer wild-type or deleted mouse T-ALLs |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
C57BL6 mice harboring Pten enhancer (PE) conditional knockout NOTCH1-induced leukemias were treated with vehicle (control) or tamoxifen to induce isogenic deletion of PE. Here we report the gene expression profile of leukemic blasts obtained from the spleen from control- or tamoxifen-treated leukemic mice. GSEA analysis show a significant enrichment of Pten signature genes, consistent with a role of PE in regulating Pten expression.
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| |
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| Overall design |
RNAseq analysis of leukemic spleens in two genotypes and four or five samples per genotype.
|
| |
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| Contributor(s) |
Tottone L, Singh A, Khiabanian H, Herranz D |
| Citation(s) |
33458694 |
| |
| Submission date |
May 20, 2020 |
| Last update date |
Mar 18, 2021 |
| Contact name |
Daniel Herranz |
| E-mail(s) |
dh710@cinj.rutgers.edu
|
| Organization name |
Rutgers Cancer Institute of New Jersey
|
| Street address |
195 Little Albany Street
|
| City |
New Brunswick |
| State/province |
New Jersey |
| ZIP/Postal code |
08901 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
|
| Samples (9)
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|
| Relations |
| BioProject |
PRJNA634002 |
| SRA |
SRP262417 |
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