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Series GSE122462 Query DataSets for GSE122462
Status Public on Feb 18, 2019
Title Anti-cancer drugs curaxins target the 3D genome organization [ChIP-seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We have recently discovered a class of anti-cancer agents, curaxins, which suppress transcription of oncogenes. Here we demonstrate that curaxins preferentially downregulate expression of genes controlled by enhancers and super-enhancers via interrupting enhancer/promoter spatial communication. Our observations made both on a model of enhancer-regulated transcription of chromatinized template and on cultured cancer cells allow classifying curaxins as a novel type of epigenetic drugs that target the 3D genome organization.
Overall design Processed and raw ChIP-seq data for control and CBL0137-treated HT1080 cells.
Please note that [1] each bigwig processed data file was generated from both ChIP and input sample data, and is linked to the corresponding ChIP sample records [2] the bed files were generated from all 8 sample data.
Contributor(s) Luzhin A, Razin S
Citation(s) 30926878
Submission date Nov 13, 2018
Last update date Apr 09, 2019
Contact name Artem Luzhin
Organization name Institute of Gene Biology RAS
Street address Vavilova 34/5
City Moscow
ZIP/Postal code 119334
Country Russia
Platforms (1)
GPL21697 NextSeq 550 (Homo sapiens)
Samples (8)
GSM3466810 Chip_library_Control_replicate1
GSM3466811 ChIP_library_CBL0137treated_replicate1
GSM3466812 ChIP_library_Conrtol_replicate2
This SubSeries is part of SuperSeries:
GSE122463 Anti-cancer drugs curaxins target the 3D genome organization
BioProject PRJNA505308
SRA SRP168424

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE122462_CBL_PePr_peaks.bed.gz 1.3 Mb (ftp)(http) BED
GSE122462_Control_PePr_peaks.bed.gz 2.1 Mb (ftp)(http) BED
GSE122462_Diff_intra_PePr_CBL_peaks.bed.gz 106.5 Kb (ftp)(http) BED
GSE122462_Diff_intra_PePr_Control_peaks.bed.gz 1.2 Mb (ftp)(http) BED
GSE122462_RAW.tar 2.1 Gb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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