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Series GSE118453 Query DataSets for GSE118453
Status Public on Aug 14, 2018
Title Ehrlichia chaffeensis TRP47 binding sites in human genome
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Ehrlichia chaffeensis is an obligately intracellular bacterium that establishes infection in mononuclear phagocytes through largely undefined reprogramming strategies. Recently, E. chaffeensis effectors Ank200, TRP120, and TRP32 have been shown to function as nucleomodulins that enter the host nucleus and directly modulate transcription of genes implicated in cellular processes such as transcription regulation, apoptosis, phosphorylation, and immune cell activation. In this study, we found that E. chaffeensis TRP47 enters the host cell nucleus and binds regulatory regions of multiple host genes relevant to infection.
Overall design ChIP-seq was performed using E. chaffensis-infected THP-1 cells at 48 hpi.
Contributor(s) Kibler CE, McBride JW
Citation(s) 30408047
Submission date Aug 13, 2018
Last update date Nov 13, 2018
Contact name Clayton Eugene Kibler
Phone 281-755-6203
Organization name UTMB
Department Pathology
Lab Keiller 1.136
Street address 301 University Blvd
City Galveston
State/province TX
ZIP/Postal code 77550
Country USA
Platforms (1)
GPL18460 Illumina HiSeq 1500 (Homo sapiens)
Samples (2)
GSM3330435 TRP47
GSM3330436 Serum
BioProject PRJNA485704
SRA SRP157613

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE118453_RAW.tar 3.0 Mb (http)(custom) TAR (of NARROWPEAK)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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