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| Status |
Public on Jun 18, 2008 |
| Title |
Regulation of skeletal muscle gene expression by synthetic drugs and exercise |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Exercise training increases endurance by inducing global gene expression changes in skeletal muscles. The extent to which the genetic effects of exercise can be mimicked by synthetic drugs is unknown.
We measured global skeletal muscle expression in sedentary and exercised mice treated with vehicle or PPARdelta ligand GW1516. PPARdelta is a transcriptional regulator of muscle oxidative metabolism and fatigue resistance.
Keywords: Pharmacology study
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| Overall design |
Sedentary and exercise trained C57Bl/6J mice were treated with vehicle or GW1516 for 4 weeks, followed by collection of quadriceps for gene expression analysis.
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| Contributor(s) |
Narkar V, Evans R |
| Citation(s) |
18674809 |
| |
| Submission date |
Jun 16, 2008 |
| Last update date |
May 04, 2018 |
| Contact name |
Ruth T Yu |
| Organization name |
Salk Institute
|
| Department |
Gene Expression Lab
|
| Lab |
Ronald Evans
|
| Street address |
10010 N Torrey Pines Rd
|
| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92037 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE11805 |
PPARdelta ligand GW1516, AMPK agonist AICAR, and exercise training |
|
| Relations |
| BioProject |
PRJNA109085 |
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