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| Status |
Public on Apr 01, 2018 |
| Title |
Effect of topical treatment with either lung surfactant or selective MMP inhibitor on excisional wounds in mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The aim of the study was to investigate the effect of bovine lung surfactant or selective MMP inhibition on skin wound healing. Excisional wounds were treated in one subpart of the study with Alveofact or control and in the other with a selective MMP-3 inhibitor UK 370106 in different concentrations.
Lung surfactant and selective MMP-3 inhibitor reduced expression of pro-inflammatory mediators. Lung surfactant treatment activated genes for cell migration and against fibrosis.
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| Overall design |
Results from eight loops that map to eight different groups and two different observation points (day 8 and day 14) are compared in this study. The samples are excised wounds at day 8 or 14. Each sample includes 8-9 raw files which represent technical replicates.
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| Contributor(s) |
Mirastschijski U, Lindner P, Stahl F, von der Haar M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Feb 09, 2018 |
| Last update date |
Apr 02, 2018 |
| Contact name |
Frank Stahl |
| E-mail(s) |
stahl@iftc.uni-hannover.de
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| Phone |
0511-7622968
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| Organization name |
Universität Hannover
|
| Department |
Institut für Technische Chemie
|
| Street address |
Callinstr. 3
|
| City |
Hannover |
| ZIP/Postal code |
30167 |
| Country |
Germany |
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| Platforms (1) |
| GPL24597 |
Mus musculus Wound Tissue Array |
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| Samples (36)
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| Relations |
| BioProject |
PRJNA433684 |
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