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Series GSE106961 Query DataSets for GSE106961
Status Public on Feb 28, 2018
Title Conjunctival transcriptome profiling of Solomon Islanders with active trachoma but without ocular Chlamydia trachomatis infection.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The prevalence of trachomatous inflammation–follicular (TF) in Solomon Island children aged 1–9 years is high enough to warrant, among other interventions, mass distribution of azithromycin. However, over 90% of those with TF did not have concurrent Chlamydia trachomatis infection.
We analysed the transcriptome of children with TF and Ct infection, children diagnosed with TF but no Ct infection and children with neither TF nor Ct infection to better understand host responses during an episode of TF, and investigate whether it can provide any clues about the aetiology of TF in this context.
Overall design Purified RNA from children with and without active trachoma was run on Affimetrix GeneChip HTA 2.0. Transcriptome profiles were compared between individuals with ocular Chlamydia trachomatis (Ct) infection and trachomatous inflammation-follicular (TF) (DI group: n=6), individuals with TF but no Ct infection (D group: n=7) and individuals without TF or Ct infection (N group: n=7). Differentially expressed (DE) genes were considered in isolation and also assessed for host response pathway membership.
Contributor(s) Vasileva H, Butcher R, Roberts CH
Citation(s) 29467021
Submission date Nov 15, 2017
Last update date Jun 14, 2022
Contact name Hristina Chavdarova Vasileva
Phone 0207 927 2195
Organization name LSHTM
Department CRD
Lab Keppel street 246
Street address Keppel Street
City London
State/province London
ZIP/Postal code WC1E 7HT
Country United Kingdom
Platforms (1)
GPL17586 [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
Samples (20)
GSM2858343 DI1
GSM2858344 DI2
GSM2858345 DI3
BioProject PRJNA418586

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Supplementary file Size Download File type/resource
GSE106961_RAW.tar 405.2 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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