|
| Status |
Public on Aug 18, 2017 |
| Title |
Mutant p53 Shapes the Enhancer Landscape of Cancer Cells in Response to Chronic Immune Signaling |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
Expression profiling by high throughput sequencing
Other
|
| Summary |
We establish a mechanism by which chronic TNF-a signaling orchestrates a functional interplay between mutant p53 and NFkB that underlies altered patterns of cancer promoting gene expression.
|
| |
|
| Overall design |
examination of various histone mark accumulation; mutp53, NFkB, RNAPII binding; and nascent transcription upon chronic TNF signaling in SW480 colon cancer cells
|
| |
|
| Contributor(s) |
Rahnamoun H, Lu H, Duttke SH, Benner C, Glass CK |
| Citation(s) |
28963538, 30076409 |
| |
| Submission date |
Aug 18, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Shannon M Lauberth |
| E-mail(s) |
slauberth@ucsd.edu
|
| Organization name |
UCSD
|
| Department |
Biological Sciences
|
| Lab |
Lauberth Lab
|
| Street address |
9500 Gilman Drive #0322, Bonner Hall 3202
|
| City |
San Diego |
| State/province |
California |
| ZIP/Postal code |
92093 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (17)
|
|
| Relations |
| BioProject |
PRJNA399115 |
| SRA |
SRP115797 |
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