|
| Status |
Public on Jan 14, 2019 |
| Title |
Inhibition of SF3B1 by molecules targeting the spliceosome in Rh18 cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
In order to examine the effects of sudemycin D1 on the whole transcriptome, we exposed Rh18 cells to 1μM of drug for 8hr and after extraction, subjected RNA to RNAseq analysis. Control samples were treated with the vehicle (DMSO) alone and all analyses were conducted in triplicate.
|
| |
|
| Overall design |
Compare differentially expressed genes in sudemycin treated verses control group.
|
| |
|
| Contributor(s) |
Wu G, Potter PM |
| Citation(s) |
29844105 |
| Submission date |
Aug 11, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Timothy Isham Shaw |
| E-mail(s) |
gatechatl@gmail.com
|
| Organization name |
St Jude Children's Research Hospital
|
| Department |
Computational Biology
|
| Street address |
262 Danny Thomas Pl
|
| City |
Memphis |
| State/province |
TN |
| ZIP/Postal code |
38105 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (6)
|
| GSM2740398 |
921375_SJRHB010470_C9-Rh18-SUD-8h-rep1 |
| GSM2740399 |
921376_SJRHB010470_C10-Rh18-SUD-8h-rep2 |
| GSM2740400 |
921377_SJRHB010470_C11-Rh18-SUD-8h-rep3 |
|
| Relations |
| BioProject |
PRJNA397981 |
| SRA |
SRP115272 |
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