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    TRB T cell receptor beta locus [ Homo sapiens (human) ]

    Gene ID: 6957, updated on 15-Jan-2024

    Summary

    Official Symbol
    TRBprovided by HGNC
    Official Full Name
    T cell receptor beta locusprovided by HGNC
    Primary source
    HGNC:HGNC:12155
    See related
    AllianceGenome:HGNC:12155
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TCRB; TRB@
    Summary
    T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. [provided by RefSeq, Jul 2008]
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    Genomic context

    See TRB in Genome Data Viewer
    Location:
    7q34
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (142299011..142813287)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (143614080..144169005)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (141998851..142510972)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9540 Neighboring gene serine protease 59, pseudogene Neighboring gene PRSS3 pseudogene 3 Neighboring gene uncharacterized LOC105375539 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:142032227-142032727 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:142044797-142045298 Neighboring gene T cell receptor beta variable 3-1 Neighboring gene T cell receptor beta variable 4-1 Neighboring gene T cell receptor beta variable 1 (pseudogene) Neighboring gene T cell receptor beta variable 2 Neighboring gene T cell receptor beta variable 5-1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:142265914-142266545 Neighboring gene T cell receptor beta variable 6-1 Neighboring gene T cell receptor beta variable 7-1 (non-functional) Neighboring gene T cell receptor beta variable 4-2 Neighboring gene T cell receptor beta variable 6-3 Neighboring gene T cell receptor beta variable 7-2 Neighboring gene T cell receptor beta variable 8-1 (pseudogene) Neighboring gene T cell receptor beta variable 5-2 (pseudogene) Neighboring gene T cell receptor beta variable 6-4 Neighboring gene T cell receptor beta variable 7-3 Neighboring gene T cell receptor beta variable 8-2 (pseudogene) Neighboring gene T cell receptor beta variable 5-3 (non-functional) Neighboring gene T cell receptor beta variable 10-1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:142190619-142191818 Neighboring gene T cell receptor beta variable 11-1 Neighboring gene T cell receptor beta variable 12-1 (pseudogene) Neighboring gene T cell receptor beta variable 9 Neighboring gene T cell receptor beta variable 10-2 Neighboring gene uncharacterized LOC107986855 Neighboring gene T cell receptor beta variable 11-2 Neighboring gene T cell receptor beta variable 12-2 (pseudogene) Neighboring gene T cell receptor beta variable 6-5 Neighboring gene T cell receptor beta variable 7-4 Neighboring gene T cell receptor beta variable 5-4 Neighboring gene microRNA 11400 Neighboring gene T cell receptor beta variable 6-6 Neighboring gene T cell receptor beta variable 7-5 (pseudogene) Neighboring gene T cell receptor beta variable 5-5 Neighboring gene T cell receptor beta variable 6-7 (non-functional) Neighboring gene T cell receptor beta variable 7-6 Neighboring gene T cell receptor beta variable 5-6 Neighboring gene T cell receptor beta variable 6-8 Neighboring gene T cell receptor beta variable 7-7 Neighboring gene T cell receptor beta variable 5-7 (non-functional) Neighboring gene T cell receptor beta variable 7-9 Neighboring gene T cell receptor beta variable 10-3 Neighboring gene T cell receptor beta variable 13 Neighboring gene T cell receptor beta variable 11-3 Neighboring gene T cell receptor beta variable 12-3 Neighboring gene T cell receptor beta variable 12-4 Neighboring gene T cell receptor beta variable 12-5 Neighboring gene Sharpr-MPRA regulatory region 1556/5446 Neighboring gene T cell receptor beta variable 14 Neighboring gene T cell receptor beta variable 15 Neighboring gene T cell receptor beta variable 16 Neighboring gene T cell receptor beta variable 17 (non-functional) Neighboring gene T cell receptor beta variable 20-1 Neighboring gene T cell receptor beta variable 18 Neighboring gene Sharpr-MPRA regulatory region 11750 Neighboring gene T cell receptor beta variable 19 Neighboring gene T cell receptor beta variable 21-1 (pseudogene) Neighboring gene MPRA-validated peak6801 silencer Neighboring gene T cell receptor beta variable 22-1 (pseudogene) Neighboring gene T cell receptor beta variable 23-1 (non-functional) Neighboring gene T cell receptor beta variable 24-1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:142403795-142404426 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:142404427-142405058 Neighboring gene MT-RNR2 like 6 (pseudogene) Neighboring gene T cell receptor beta variable 25-1 Neighboring gene T cell receptor beta variable A (pseudogene) Neighboring gene T cell receptor beta variable 26 (pseudogene) Neighboring gene uncharacterized LOC124901763 Neighboring gene piggyBac transposable element derived 4 pseudogene 1 Neighboring gene T cell receptor beta variable 27 Neighboring gene T cell receptor beta variable 28 Neighboring gene T cell receptor beta variable B (pseudogene) Neighboring gene T cell receptor beta variable 29-1 Neighboring gene uncharacterized LOC124901762 Neighboring gene PRSS3 pseudogene 1 Neighboring gene CRISPRi-validated cis-regulatory element chr7.5162 Neighboring gene serine protease 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:142506073-142507272 Neighboring gene uncharacterized LOC105375541 Neighboring gene WBP1L pseudogene 1 Neighboring gene serine protease 2 Neighboring gene T cell receptor beta joining 1-3 Neighboring gene T cell receptor beta joining 1-2 Neighboring gene T cell receptor beta joining 1-1 Neighboring gene T cell receptor beta joining 1-4 Neighboring gene T cell receptor beta joining 1-5 Neighboring gene T cell receptor beta joining 1-6 Neighboring gene T cell receptor beta joining 2-2P (non-functional) Neighboring gene T cell receptor beta joining 2-1 Neighboring gene CRISPRi-validated cis-regulatory element chr7.5168 Neighboring gene T cell receptor beta joining 2-2 Neighboring gene T cell receptor beta joining 2-3 Neighboring gene T cell receptor beta joining 2-4 Neighboring gene T cell receptor beta joining 2-5 Neighboring gene T cell receptor beta joining 2-6 Neighboring gene T cell receptor beta joining 2-7 Neighboring gene T cell receptor beta diversity 1 Neighboring gene T cell receptor beta constant 1 Neighboring gene T cell receptor beta diversity 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:142564181-142564714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:142564989-142565924 Neighboring gene T cell receptor beta constant 2 Neighboring gene T cell receptor beta variable 30 Neighboring gene EPH receptor B6

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
    EBI GWAS Catalog
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Other Names

    • M1-specific T cell receptor beta chain
    • T-cell antigen receptor, beta polypeptide, T-cell receptor, beta cluster
    • T-cell receptor, beta cluster
    • TCRB, TRB@
    • TR beta chain TRBV19*01J2S7*01C*02

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of alpha-beta T cell receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Names
    T cell receptor beta locus
    M1-specific T cell receptor beta chain
    T-cell antigen receptor, beta polypeptide, T-cell receptor, beta cluster
    T-cell receptor, beta cluster
    TCRB, TRB@
    TR beta chain TRBV19*01J2S7*01C*02

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_001333.2 

      Range
      91557..667340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      142299011..142813287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187562.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      260931..836260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      143614080..144169005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)