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    TEKT3 tektin 3 [ Homo sapiens (human) ]

    Gene ID: 64518, updated on 11-Apr-2024

    Summary

    Official Symbol
    TEKT3provided by HGNC
    Official Full Name
    tektin 3provided by HGNC
    Primary source
    HGNC:HGNC:14293
    See related
    Ensembl:ENSG00000125409 MIM:612683; AllianceGenome:HGNC:14293
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPGF81
    Summary
    This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 5.3) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TEKT3 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (15303812..15343671, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (15209840..15249701, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (15207129..15244914, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8211 Neighboring gene uncharacterized LOC124903931 Neighboring gene peripheral myelin protein 22 Neighboring gene microRNA 4731 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:15181646-15182845 Neighboring gene uncharacterized LOC124903932 Neighboring gene RNA, U6 small nuclear 799, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:15313079-15313579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:15320989-15321490 Neighboring gene RNA, 7SL, cytoplasmic 792, pseudogene Neighboring gene TVP23C-CDRT4 readthrough Neighboring gene CMT1A duplicated region transcript 4 Neighboring gene ribosomal protein L9 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ32828

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_positive_effect regulation of brood size ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in acrosomal vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in axonemal A tubule inner sheath IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axonemal microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular exosome HDA PubMed 
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus HDA PubMed 
    located_in outer acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    tektin-3
    Names
    testicular microtubules-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031898.3NP_114104.1  tektin-3

      See identical proteins and their annotated locations for NP_114104.1

      Status: REVIEWED

      Source sequence(s)
      AF334676, BC031688
      Consensus CDS
      CCDS11169.1
      UniProtKB/Swiss-Prot
      B2RAS7, D3DTT0, Q8N5R5, Q96M48, Q9BXF9
      UniProtKB/TrEMBL
      Q53EV5
      Related
      ENSP00000379263.1, ENST00000395930.6
      Conserved Domains (1) summary
      pfam03148
      Location:99478
      Tektin; Tektin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      15303812..15343671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024954.2XP_016880443.1  tektin-3 isoform X1

      UniProtKB/Swiss-Prot
      B2RAS7, D3DTT0, Q8N5R5, Q96M48, Q9BXF9
      UniProtKB/TrEMBL
      Q53EV5
      Conserved Domains (1) summary
      pfam03148
      Location:99478
      Tektin; Tektin family
    2. XM_011523989.2XP_011522291.1  tektin-3 isoform X1

      See identical proteins and their annotated locations for XP_011522291.1

      UniProtKB/Swiss-Prot
      B2RAS7, D3DTT0, Q8N5R5, Q96M48, Q9BXF9
      UniProtKB/TrEMBL
      Q53EV5
      Related
      ENSP00000343995.2, ENST00000338696.6
      Conserved Domains (1) summary
      pfam03148
      Location:99478
      Tektin; Tektin family
    3. XM_017024955.2XP_016880444.1  tektin-3 isoform X2

      Conserved Domains (1) summary
      pfam03148
      Location:1312
      Tektin; Tektin family
    4. XM_011523990.3XP_011522292.1  tektin-3 isoform X2

      Conserved Domains (1) summary
      pfam03148
      Location:1312
      Tektin; Tektin family
    5. XM_011523988.3XP_011522290.1  tektin-3 isoform X1

      See identical proteins and their annotated locations for XP_011522290.1

      UniProtKB/Swiss-Prot
      B2RAS7, D3DTT0, Q8N5R5, Q96M48, Q9BXF9
      UniProtKB/TrEMBL
      Q53EV5
      Conserved Domains (1) summary
      pfam03148
      Location:99478
      Tektin; Tektin family
    6. XM_017024956.2XP_016880445.1  tektin-3 isoform X3

      UniProtKB/TrEMBL
      J3KPT7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      15209840..15249701 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316930.1XP_054172905.1  tektin-3 isoform X1

    2. XM_054316928.1XP_054172903.1  tektin-3 isoform X1

    3. XM_054316932.1XP_054172907.1  tektin-3 isoform X2

    4. XM_054316931.1XP_054172906.1  tektin-3 isoform X2

    5. XM_054316929.1XP_054172904.1  tektin-3 isoform X1

    6. XM_054316933.1XP_054172908.1  tektin-3 isoform X3