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    MYOG myogenin [ Homo sapiens (human) ]

    Gene ID: 4656, updated on 5-Mar-2024

    Summary

    Official Symbol
    MYOGprovided by HGNC
    Official Full Name
    myogeninprovided by HGNC
    Primary source
    HGNC:HGNC:7612
    See related
    Ensembl:ENSG00000122180 MIM:159980; AllianceGenome:HGNC:7612
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MYF4; myf-4; bHLHc3
    Summary
    Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in prostate (RPKM 2.6) and esophagus (RPKM 0.9) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    1q32.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (203083129..203086012, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (202345882..202348764, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (203052257..203055140, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:202975854-202976628 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:202976629-202977401 Neighboring gene transmembrane protein 183A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:202995545-202996066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2340 Neighboring gene PTPRF interacting protein alpha 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203010223-203010724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203010725-203011224 Neighboring gene Sharpr-MPRA regulatory region 9252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203013943-203014581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203014582-203015219 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:203015372-203015574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:203017091-203017988 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:203020635-203021176 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:203023677-203024428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203024429-203025180 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:203030137-203030721 Neighboring gene uncharacterized LOC105371687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2341 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:203044947-203045682 Neighboring gene NANOG hESC enhancer GRCh37_chr1:203056459-203056976 Neighboring gene myogenin promoter associated myogenic regulatory antisense long non coding RNA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203096578-203097558 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:203103311-203104198 Neighboring gene adenosine A1 receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203112572-203113072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203114546-203115227 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:203134798-203134977 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:203135305-203135815 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:203135816-203136326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203138876-203139876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203143089-203143618 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:203146536-203147735 Neighboring gene myosin binding protein H Neighboring gene chitinase 3 like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific TAS
    Traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables E-box binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chromatin DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to estradiol stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lithium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in muscle cell fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ossification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of muscle atrophy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of myoblast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of myoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of myotube differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of skeletal muscle fiber development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of skeletal muscle fiber development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of myoblast fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of skeletal muscle satellite cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to denervation involved in regulation of muscle adaptation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to electrical stimulus involved in regulation of muscle adaptation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to muscle activity involved in regulation of muscle adaptation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in skeletal muscle cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in skeletal muscle fiber development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal muscle tissue development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in striated muscle atrophy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-DNA complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription regulator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    myogenin
    Names
    class C basic helix-loop-helix protein 3
    myogenic factor 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002479.6NP_002470.2  myogenin

      See identical proteins and their annotated locations for NP_002470.2

      Status: VALIDATED

      Source sequence(s)
      AC105940, BC053899
      Consensus CDS
      CCDS1433.1
      UniProtKB/Swiss-Prot
      P15173, Q53XW6
      UniProtKB/TrEMBL
      Q9HCA4
      Related
      ENSP00000241651.4, ENST00000241651.5
      Conserved Domains (2) summary
      smart00520
      Location:186
      BASIC; Basic domain in HLH proteins of MYOD family
      cd18935
      Location:81139
      bHLH_TS_MYOG_Myf4; basic helix-loop-helix (bHLH) domain found in myogenin (MYOG) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      203083129..203086012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      202345882..202348764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)