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    KRTAP10-3 keratin associated protein 10-3 [ Homo sapiens (human) ]

    Gene ID: 386682, updated on 5-Mar-2024

    Summary

    Official Symbol
    KRTAP10-3provided by HGNC
    Official Full Name
    keratin associated protein 10-3provided by HGNC
    Primary source
    HGNC:HGNC:22968
    See related
    Ensembl:ENSG00000212935 AllianceGenome:HGNC:22968
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KAP10.3; KAP18-3; KAP18.3; KRTAP10.3; KRTAP18-3; KRTAP18.3
    Summary
    This gene encodes a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This gene encodes a member of the high sulfur KAP family. It is localized to a cluster of intronless KAPs at 21q22.3 which are located within the introns of the C21orf29 gene. [provided by RefSeq, Jul 2008]
    Orthologs
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    Genomic context

    Location:
    21q22.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (44557790..44558795, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (42918193..42919198, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (45977673..45978678, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene thrombospondin type laminin G domain and EAR repeats Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45958816-45959480 Neighboring gene keratin associated protein 10-1 Neighboring gene Sharpr-MPRA regulatory region 850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45969969-45970518 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45970519-45971066 Neighboring gene keratin associated protein 10-2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45993821-45994338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45994339-45994857 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45999625-46000215 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46000216-46000805 Neighboring gene keratin associated protein 10-4 Neighboring gene keratin associated protein 10-5

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    keratin-associated protein 10-3
    Names
    high sulfur keratin-associated protein 10.3
    keratin-associated protein 18-3
    keratin-associated protein 18.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050765.1 RefSeqGene

      Range
      4966..5971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_198696.3NP_941969.2  keratin-associated protein 10-3

      See identical proteins and their annotated locations for NP_941969.2

      Status: REVIEWED

      Source sequence(s)
      AB076350, AJ566383, AP001067
      Consensus CDS
      CCDS42956.1
      UniProtKB/Swiss-Prot
      A3KN67, P60369, Q70LJ4
      Related
      ENSP00000375478.1, ENST00000391620.2
      Conserved Domains (2) summary
      pfam01500
      Location:78203
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam13885
      Location:79123
      Keratin_B2_2; Keratin, high sulfur B2 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      44557790..44558795 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      42918193..42919198 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)