vegfaa vascular endothelial growth factor Aa [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: vegfaaprovided by ZNC
Official Full Name: vascular endothelial growth factor Aaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-273
See related: Ensembl:ENSDARG00000103542 AllianceGenome:ZFIN:ZDB-GENE-990415-273
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: vegf; vegfa; wu:fj82c06
Summary: Enables growth factor activity. Acts upstream of or within several processes, including animal organ development; circulatory system development; and regulation of vasculature development. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; mesoderm; nervous system; pleuroperitoneal region; and podocyte. Used to study proteinuria. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human VEGFA (vascular endothelial growth factor A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (4287542..4317940, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (4459314..4488660, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Local angiogenic interplay of Vegfc/d and Vegfa controls brain region-specific emergence of fenestrated capillaries.
Title: Local angiogenic interplay of Vegfc/d and Vegfa controls brain region-specific emergence of fenestrated capillaries.
Brain endothelial cells acquire blood-brain barrier properties in the absence of Vegf-dependent CNS angiogenesis.
Title: Brain endothelial cells acquire blood-brain barrier properties in the absence of Vegf-dependent CNS angiogenesis.
Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition.
Title: Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition.
dnVegfaa and sFlt1 have different roles in zebrafish pancreatic vasculature and islet development
Title: Disruption of the pancreatic vasculature in zebrafish affects islet architecture and function.
Up-regulation of VEGF signaling rescues angiogenic intersegmental vessel growth defects caused by arfgef2 knockdown. VEGF was ubiquitously expressed during gastrulation and segmentation stages. VEGF is spatially and temporally correlated with angioblast differentiation and migration during early zebrafish embryonic development.
Title: Involvement of BIG1 and BIG2 in regulating VEGF expression and angiogenesis.
zebrafish macrophages can enhance Vegfa-driven tumour angiogenesis.
Title: Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model.
Knockdown of transmembrane protein 33 (tmem33) impairs multiple downstream effects of vascular endothelial growth factor (VEGF).
Title: tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis.
GDF6 promotes vascular stabilization by restraining vascular endothelial growth factor signaling.
Title: Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling.
Vegfaa role in the venous sprouting and spinal cord vascularization.
Title: Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization.
findings identify Vegfa as one of a select few known factors sufficient to activate adult cardiomyogenesis, while also illustrating how instructive factors for heart regeneration require spatiotemporal control for efficacy.
Title: Vegfaa instructs cardiac muscle hyperplasia in adult zebrafish.

Submit: New GeneRIF Correction See all GeneRIFs (45)

General gene information

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Markers

fj82c06.x1 (e-PCR)
- UniSTS:200020

fj31h07.y1 (e-PCR)
- UniSTS:199053

vegf (e-PCR), detects polymorphism
- UniSTS:205471

vegf (e-PCR), detects polymorphism
- UniSTS:187046

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chemoattractant activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IMP Inferred from Mutant Phenotype more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables vascular endothelial growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angioblast cell migration from lateral mesoderm to midline	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within angiogenesis	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardioblast migration to the midline involved in heart rudiment formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within central nervous system vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocardial progenitor cell migration to the midline involved in heart field formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hemopoiesis	IDA Inferred from Direct Assay more info
involved_in hemopoiesis	IMP Inferred from Mutant Phenotype more info
involved_in induction of positive chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within motor neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mast cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of angioblast cell migration involved in selective angioblast sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of vasculature development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to glucose	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info
involved_in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thyroid gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vascular endothelial growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vasculature development	IGI Inferred from Genetic Interaction more info
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculogenesis	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasculogenesis	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within venous blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vascular endothelial growth factor A-A

Names: VEGF-A-A; etID309976.16; vascular endothelial growth factor A; vegf-a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110349.2 → NP_001103819.2 vascular endothelial growth factor A-A isoform 2 precursor

See identical proteins and their annotated locations for NP_001103819.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) is lacking an in-frame, coding exon compared to transcript variant 1, resulting in a shorter isoform (2) that is missing a 44 aa segment, compared to isoform 1.

Source sequence(s)

AF059661

UniProtKB/Swiss-Prot

O73682

Conserved Domains (1) summary

smart00141
Location:47 → 129

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
NM_131408.3 → NP_571483.1 vascular endothelial growth factor A-A isoform 1 precursor

See identical proteins and their annotated locations for NP_571483.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AF016244

UniProtKB/Swiss-Prot

B3DG34, O73682, O73822

Related

ENSDARP00000133415.1, ENSDART00000167719.2

Conserved Domains (2) summary

smart00141
Location:47 → 129

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam14554
Location:136 → 188

VEGF_C; VEGF heparin-binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

4287542..4317940 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009292018.4 → XP_009290293.1 vascular endothelial growth factor A-A isoform X1

UniProtKB/TrEMBL

A0A8M3AHS3

Conserved Domains (1) summary

pfam00341
Location:49 → 127

PDGF; PDGF/VEGF domain
XM_068213886.1 → XP_068069987.1 vascular endothelial growth factor A-A isoform X2