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    SLC22A31 solute carrier family 22 member 31 [ Homo sapiens (human) ]

    Gene ID: 146429, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SLC22A31provided by HGNC
    Official Full Name
    solute carrier family 22 member 31provided by HGNC
    Primary source
    HGNC:HGNC:27091
    See related
    Ensembl:ENSG00000259803 AllianceGenome:HGNC:27091
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in ion transport and transmembrane transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
    Expression
    Biased expression in lung (RPKM 12.0), pancreas (RPKM 1.5) and 2 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    16q24.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (89195761..89201678, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (95275967..95281802, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (89262169..89268086, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89233179-89234027 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89234028-89234875 Neighboring gene long intergenic non-protein coding RNA 2138 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7893 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89241373-89241872 Neighboring gene cadherin 15 Neighboring gene Sharpr-MPRA regulatory region 11767 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11396 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7894 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89260181-89260846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89265225-89265848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89267097-89267719 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7895 Neighboring gene Sharpr-MPRA regulatory region 4154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11397 Neighboring gene ZNF778 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89284467-89284997 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89284998-89285527 Neighboring gene zinc finger protein 778 Neighboring gene Sharpr-MPRA regulatory region 2584

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Whole-genome sequencing reveals host factors underlying critical COVID-19. Kousathanas A, et al. Nature, 2022 Jul. PMID 35255492, Free PMC Article
    2. The sequence and analysis of duplication-rich human chromosome 16. Martin J, et al. Nature, 2004 Dec 23. PMID 15616553

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative solute carrier family 22 member 31
    Names
    putative solute carrier family 22 member ENSG00000182157

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001366322.1 → NP_001353251.1  putative solute carrier family 22 member 31 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC009113

    2. NM_001384763.1 → NP_001371692.1  putative solute carrier family 22 member 31 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC009113
      Consensus CDS
      CCDS92209.1
      Related
      ENSP00000508250.1, ENST00000682282.1
      Conserved Domains (1) summary
      cl28910
      Location:9 → 383
      MFS; Major Facilitator Superfamily

    3. NM_001384764.1 → NP_001371693.1  putative solute carrier family 22 member 31 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC009113
      Conserved Domains (1) summary
      cl28910
      Location:1 → 316
      MFS; Major Facilitator Superfamily

    4. NM_001384765.1 → NP_001371694.1  putative solute carrier family 22 member 31 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC009113
      Conserved Domains (2) summary
      TIGR00898
      Location:4 → 115
      2A0119; cation transport protein
      cl28910
      Location:1 → 187
      MFS; Major Facilitator Superfamily

    5. NM_001384766.1 → NP_001371695.1  putative solute carrier family 22 member 31 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 6-8, encodes isoform e.
      Source sequence(s)
      AC009113
      Consensus CDS
      CCDS73927.1
      UniProtKB/TrEMBL
      A0A087WY01
      Related
      ENSP00000474621.2, ENST00000562855.7
      Conserved Domains (1) summary
      cl28910
      Location:1 → 275
      MFS; Major Facilitator Superfamily

    6. NM_001384767.1 → NP_001371696.1  putative solute carrier family 22 member 31 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 5, 7, and 8, encodes isoform e.
      Source sequence(s)
      AC009113
      Consensus CDS
      CCDS73927.1
      UniProtKB/TrEMBL
      A0A087WY01
      Conserved Domains (1) summary
      cl28910
      Location:1 → 275
      MFS; Major Facilitator Superfamily

    7. NM_001384768.1 → NP_001371697.1  putative solute carrier family 22 member 31 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 5, 6, and 8, encodes isoform e.
      Source sequence(s)
      AC009113
      Consensus CDS
      CCDS73927.1
      UniProtKB/TrEMBL
      A0A087WY01
      Conserved Domains (1) summary
      cl28910
      Location:1 → 275
      MFS; Major Facilitator Superfamily

    8. NM_001384769.1 → NP_001371698.1  putative solute carrier family 22 member 31 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 5-7, encodes isoform e.
      Source sequence(s)
      AC009113
      Consensus CDS
      CCDS73927.1
      UniProtKB/TrEMBL
      A0A087WY01
      Related
      ENSP00000481421.1, ENST00000614943.4
      Conserved Domains (1) summary
      cl28910
      Location:1 → 275
      MFS; Major Facilitator Superfamily

    9. NM_001384770.1 → NP_001371699.1  putative solute carrier family 22 member 31 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC009113
      Conserved Domains (1) summary
      cl28910
      Location:1 → 239
      MFS; Major Facilitator Superfamily

    10. NM_001384771.1 → NP_001371700.1  putative solute carrier family 22 member 31 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC009113
      Conserved Domains (1) summary
      cl28910
      Location:1 → 237
      MFS; Major Facilitator Superfamily

    11. NM_001384772.1 → NP_001371701.1  putative solute carrier family 22 member 31 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 12 and 13, encodes isoform h.
      Source sequence(s)
      AC009113
      Conserved Domains (1) summary
      cl28910
      Location:25 → 181
      MFS; Major Facilitator Superfamily

    12. NM_001384773.1 → NP_001371702.1  putative solute carrier family 22 member 31 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 11 and 13, encodes isoform h.
      Source sequence(s)
      AC009113
      Conserved Domains (1) summary
      cl28910
      Location:25 → 181
      MFS; Major Facilitator Superfamily

    13. NM_001384775.1 → NP_001371704.1  putative solute carrier family 22 member 31 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variants 11 and 12, encodes isoform h.
      Source sequence(s)
      AC009113
      Conserved Domains (1) summary
      cl28910
      Location:25 → 181
      MFS; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      89195761..89201678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433647.1 → XP_047289603.1  putative solute carrier family 22 member 31 isoform X2

    2. XM_017022962.2 → XP_016878451.1  putative solute carrier family 22 member 31 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      95275967..95281802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001242757.1: Suppressed sequence

      Description
      NM_001242757.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NKX4.4 GenPept UniProtKB/Swiss-Prot:A6NKX4

    Gene LinkOut

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