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    Arg1 arginase, liver [ Mus musculus (house mouse) ]

    Gene ID: 11846, updated on 4-Jun-2024

    Summary

    Official Symbol
    Arg1provided by MGI
    Official Full Name
    arginase, liverprovided by MGI
    Primary source
    MGI:MGI:88070
    See related
    Ensembl:ENSMUSG00000019987 AllianceGenome:MGI:88070
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI; PGIF; Arg-1
    Summary
    Enables arginase activity. Involved in defense response to protozoan; negative regulation of T-helper 2 cell cytokine production; and negative regulation of activated T cell proliferation. Predicted to be located in several cellular components, including extracellular space; mitochondrial outer membrane; and neuronal cell body. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study hyperargininemia. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 207.8) and liver E18 (RPKM 196.5) See more
    Orthologs
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    Genomic context

    See Arg1 in Genome Data Viewer
    Location:
    10 A4; 10 12.26 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (24791105..24803368, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (24915207..24927470, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 23 Neighboring gene predicted gene, 23410 Neighboring gene microRNA 6905 Neighboring gene predicted gene, 40616 Neighboring gene predicted gene, 36228 Neighboring gene STARR-seq mESC enhancer starr_26092 Neighboring gene actin, gamma, cytoplasmic 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arginase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables arginase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables arginase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables manganese ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in arginine catabolic process to ornithine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in arginine catabolic process to ornithine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in arginine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to protozoan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of T-helper 2 cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of activated T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of type II interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil mediated killing of fungus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of L-arginine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in urea cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    arginase-1
    Names
    arginase 1, liver
    arginase I
    liver-type arginase
    type I arginase
    NP_031508.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007482.3NP_031508.1  arginase-1

      See identical proteins and their annotated locations for NP_031508.1

      Status: VALIDATED

      Source sequence(s)
      AK149471, CB947842, U88541
      Consensus CDS
      CCDS48523.1
      UniProtKB/Swiss-Prot
      Q3TB74, Q3UEL0, Q4FK78, Q61176, Q80VI4
      Related
      ENSMUSP00000020161.9, ENSMUST00000020161.10
      Conserved Domains (1) summary
      cd11587
      Location:9303
      Arginase-like; Arginase types I and II and arginase-like family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      24791105..24803368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)