| Siglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket. | Siglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket.
Schmidt EN, Lamprinaki D, McCord KA, Joe M, Sojitra M, Waldow A, Nguyen J, Monyror J, Kitova EN, Mozaneh F, Guo XY, Jung J, Enterina JR, Daskhan GC, Han L, Krysler AR, Cromwell CR, Hubbard BP, West LJ, Kulka M, Sipione S, Klassen JS, Derda R, Lowary TL, Mahal LK, Riddell MR, Macauley MS., Free PMC Article | 05/4/2023 |
| Expression and regulation of Siglec-6 (CD327) on human mast cells and basophils. | Expression and regulation of Siglec-6 (CD327) on human mast cells and basophils.
Smiljkovic D, Herrmann H, Sadovnik I, Gamperl S, Berger D, Stefanzl G, Eisenwort G, Hoermann G, Kopanja S, Dorofeeva Y, Focke-Tejkl M, Jaksch P, Hoetzenecker K, Szepfalusi Z, Valenta R, Arock M, Valent P. | 01/28/2023 |
| Siglec-6 Signaling Uses Src Kinase Tyrosine Phosphorylation and SHP-2 Recruitment. | Siglec-6 Signaling Uses Src Kinase Tyrosine Phosphorylation and SHP-2 Recruitment.
Stefanski AL, Renecle MD, Kramer A, Sehgal S, Narasimhan P, Rumer KK, Winn VD., Free PMC Article | 11/26/2022 |
| Elevated trophoblastic Siglec6 contributes to the impairment of vascular endothelial cell functions by downregulating Wnt6/beta-catenin signaling in preeclampsia. | Elevated trophoblastic Siglec6 contributes to the impairment of vascular endothelial cell functions by downregulating Wnt6/β-catenin signaling in preeclampsia.
Guan X, Yu M, Wu L, Chen J, Tong J, Wu X, Yin A, Xiao T, Wang B, Zhang JV, Niu J. | 10/29/2022 |
| Siglec-6 as a New Potential Immune Checkpoint for Bladder Cancer Patients. | Siglec-6 as a New Potential Immune Checkpoint for Bladder Cancer Patients.
Benmerzoug S, Chevalier MF, Verardo M, Nguyen S, Cesson V, Schneider AK, Dartiguenave F, Rodrigues-Dias SC, Lucca I, Jichlinski P, Roth B, Nardelli-Haefliger D, Derré L. | 09/3/2022 |
| Functional and Phenotypic Characterization of Siglec-6 on Human Mast Cells. | Functional and Phenotypic Characterization of Siglec-6 on Human Mast Cells.
Robida PA, Rische CH, Morgenstern NB, Janarthanam R, Cao Y, Krier-Burris RA, Korver W, Xu A, Luu T, Schanin J, Leung J, Rothenberg ME, Wechsler JB, Youngblood BA, Bochner BS, O'Sullivan JA., Free PMC Article | 04/30/2022 |
| Glycosylated Siglec-6 expression in syncytiotrophoblast-derived extracellular vesicles from preeclampsia placentas. | Glycosylated Siglec-6 expression in syncytiotrophoblast-derived extracellular vesicles from preeclampsia placentas.
Awoyemi T, Tannetta D, Zhang W, Kandzija N, Motta-Mejia C, Fischer R, Heilig R, Raiss S, Redman C, Vatish M. | 03/20/2021 |
| Study findings illustrate that SIGLEC6 is a functionally inhibitory receptor on mast cells and suggest that SIGLEC6 expression may be relevant for mast cells activity in the tumor microenvironment of colorectal cancer. | Functional Inhibitory Siglec-6 Is Upregulated in Human Colorectal Cancer-Associated Mast Cells.
Yu Y, Blokhuis BRJ, Diks MAP, Keshavarzian A, Garssen J, Redegeld FA., Free PMC Article | 10/26/2019 |
| Siglec6 and leptin play a role in the aberrant properties characteristic of gestational trophoblastic disease, namely excess proliferation and invasion. | Siglec-6 is expressed in gestational trophoblastic disease and affects proliferation, apoptosis and invasion.
Rumer KK, Post MD, Larivee RS, Zink M, Uyenishi J, Kramer A, Teoh D, Bogart K, Winn VD., Free PMC Article | 01/4/2014 |
| Siglec-6 expression is increased in preterm preeclampsia placentas. | Siglec-6 expression is increased in placentas from pregnancies complicated by preterm preeclampsia.
Rumer KK, Uyenishi J, Hoffman MC, Fisher BM, Winn VD., Free PMC Article | 11/30/2013 |
| GdA interacts with Siglec-6 to suppress trophoblast invasiveness by down-regulating the ERK/c-Jun signaling pathway. | Glycodelin-A protein interacts with Siglec-6 protein to suppress trophoblast invasiveness by down-regulating extracellular signal-regulated kinase (ERK)/c-Jun signaling pathway.
Lam KK, Chiu PC, Lee CL, Pang RT, Leung CO, Koistinen H, Seppala M, Ho PC, Yeung WS., Free PMC Article | 12/17/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. | 04/7/2010 |
| Preeclampsia involves changes in the gene expression of SIGLEC6 in placental cytotrophoblasts. | Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2.
Winn VD, Gormley M, Paquet AC, Kjaer-Sorensen K, Kramer A, Rumer KK, Haimov-Kochman R, Yeh RF, Overgaard MT, Varki A, Oxvig C, Fisher SJ., Free PMC Article | 01/21/2010 |
| the negative signaling potential of Siglec-6 may have a role in human-specific placental expression, to slow the tempo of the human birth process | Human-specific expression of Siglec-6 in the placenta.
Brinkman-Van der Linden EC, Hurtado-Ziola N, Hayakawa T, Wiggleton L, Benirschke K, Varki A, Varki N. | 01/21/2010 |