| RGC-32 mediates proinflammatory and profibrotic pathways in immune-mediated kidney disease. | RGC-32 mediates proinflammatory and profibrotic pathways in immune-mediated kidney disease.
Tatomir A, Vlaicu S, Nguyen V, Luzina IG, Atamas SP, Drachenberg C, Papadimitriou J, Badea TC, Rus HG, Rus V. | 07/22/2024 |
| RGC-32 facilitates pancreatic cancer via activating Wnt/beta-catenin signaling. | RGC-32 facilitates pancreatic cancer via activating Wnt/β-catenin signaling.
He J, Yang G, Cao R, Zhu L. | 02/2/2024 |
| Regulator of Cell Cycle Protein (RGCC/RGC-32) Protects against Pulmonary Fibrosis. | Regulator of Cell Cycle Protein (RGCC/RGC-32) Protects against Pulmonary Fibrosis.
Luzina IG, Rus V, Lockatell V, Courneya JP, Hampton BS, Fishelevich R, Misharin AV, Todd NW, Badea TC, Rus H, Atamas SP., Free PMC Article | 02/19/2022 |
| RGC-32 Acts as a Hub to Regulate the Transcriptomic Changes Associated With Astrocyte Development and Reactive Astrocytosis. | RGC-32 Acts as a Hub to Regulate the Transcriptomic Changes Associated With Astrocyte Development and Reactive Astrocytosis.
Tatomir A, Beltrand A, Nguyen V, Courneya JP, Boodhoo D, Cudrici C, Muresanu DF, Rus V, Badea TC, Rus H., Free PMC Article | 12/25/2021 |
| RGC-32 Regulates Generation of Reactive Astrocytes in Experimental Autoimmune Encephalomyelitis. | RGC-32 Regulates Generation of Reactive Astrocytes in Experimental Autoimmune Encephalomyelitis.
Tatomir A, Beltrand A, Nguyen V, Boodhoo D, Mekala A, Cudrici C, Badea TC, Muresanu DF, Rus V, Rus H., Free PMC Article | 06/26/2021 |
| RGC-32 is a novel protein factor vital for maintaining blood pressure homeostasis, especially in individuals with low birth weight. | Response Gene to Complement 32 Maintains Blood Pressure Homeostasis by Regulating α-Adrenergic Receptor Expression.
Tang JM, Shi N, Dong K, Brown SA, Coleman AE, Boegehold MA, Chen SY., Free PMC Article | 10/5/2019 |
| this study shows that RGC-32 regulates reactive astrocytosis and extracellular matrix deposition in experimental autoimmune encephalomye | RGC-32 regulates reactive astrocytosis and extracellular matrix deposition in experimental autoimmune encephalomyelitis.
Tatomir A, Tegla CA, Martin A, Boodhoo D, Nguyen V, Sugarman AJ, Mekala A, Anselmo F, Talpos-Caia A, Cudrici C, Badea TC, Rus V, Rus H., Free PMC Article | 06/29/2019 |
| our data reveal that RGC32 promotes the onset of Systemic sclerosis by regulating the inflammatory response of M1 macrophages. | RGC32 Promotes Bleomycin-Induced Systemic Sclerosis in a Murine Disease Model by Modulating Classically Activated Macrophage Function.
Sun C, Chen SY., Free PMC Article | 04/6/2019 |
| that RGC-32 suppresses adipose tissue thermogenic gene expression through down-regulation of beta3-AR expression and mTORC1 activity via a PI3K/Akt-dependent mechanism | Response gene to complement 32 suppresses adipose tissue thermogenic genes through inhibiting β3-adrenergic receptor/mTORC1 signaling.
Chen S, Mei X, Yin A, Yin H, Cui XB, Chen SY., Free PMC Article | 03/23/2019 |
| RGC-32 may lose its expression in type 2 diabetes retina with features of diabetic retinopathy. | Loss of Response Gene to Complement 32 (RGC-32) in Diabetic Mouse Retina Is Involved in Retinopathy Development.
Liao WL, Lin JM, Liu SP, Chen SY, Lin HJ, Wang YH, Lei YJ, Huang YC, Tsai FJ., Free PMC Article | 02/23/2019 |
| RGC-32 mediates atherogenesis by facilitating monocyte-endothelial cell interaction via the induction of endothelial ICAM-1 and VCAM-1 expression, at least partially, through NF-kappaB signaling pathway. | RGC-32 (Response Gene to Complement 32) Deficiency Protects Endothelial Cells From Inflammation and Attenuates Atherosclerosis.
Cui XB, Luan JN, Dong K, Chen S, Wang Y, Watford WT, Chen SY., Free PMC Article | 01/12/2019 |
| results identify RGC-32 as a novel regulator of Th17 cell differentiation in vitro and in vivo and suggest that RGC-32 is a potential therapeutic target in multiple sclerosis and other Th17-mediated autoimmune diseases | RGC-32 Promotes Th17 Cell Differentiation and Enhances Experimental Autoimmune Encephalomyelitis.
Rus V, Nguyen V, Tatomir A, Lees JR, Mekala AP, Boodhoo D, Tegla CA, Luzina IG, Antony PA, Cudrici CD, Badea TC, Rus HG., Free PMC Article | 09/23/2017 |
| results demonstrate that RGC-32 contributes to the development of hepatic steatosis by facilitating de novo lipogenesis through activating liver X receptor, leading to the induction of SREBP-1c and its target genes | RGC-32 Deficiency Protects against Hepatic Steatosis by Reducing Lipogenesis.
Cui XB, Luan JN, Chen SY., Free PMC Article | 12/12/2015 |
| RGC-32 is involved in controlling the cell cycle of T cells in vivo, and this effect is mediated by IL-2 in a PI3K-dependent fashion. | RGC-32 is a novel regulator of the T-lymphocyte cell cycle.
Tegla CA, Cudrici CD, Nguyen V, Danoff J, Kruszewski AM, Boodhoo D, Mekala AP, Vlaicu SI, Chen C, Rus V, Badea TC, Rus H., Free PMC Article | 08/1/2015 |
| RGC32 plays an important role in diet-induced obesity and insulin resistance, and thus it may serve as a potential novel drug target for developing therapeutics to treat obesity and metabolic disorders. | RGC32 deficiency protects against high-fat diet-induced obesity and insulin resistance in mice.
Cui XB, Luan JN, Ye J, Chen SY., Free PMC Article | 04/18/2015 |
| results demonstrate for the first time that RGC-32 is a novel membrane regulator for macrophage phagocytosis. | Response gene to complement 32 protein promotes macrophage phagocytosis via activation of protein kinase C pathway.
Tang R, Zhang G, Chen SY., Free PMC Article | 12/20/2014 |
| knockdown of RGC-32 by shRNA inhibited VEGF-induced endothelial cell proliferation, migration, and tube formation while blocking VEGFR2 expression. | Response gene to complement 32 deficiency causes impaired placental angiogenesis in mice.
Cui XB, Guo X, Chen SY., Free PMC Article | 05/3/2014 |
| RGC-32 as a novel fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. | Response gene to complement 32 is essential for fibroblast activation in renal fibrosis.
Li Z, Xie WB, Escano CS, Asico LD, Xie Q, Jose PA, Chen SY., Free PMC Article | 01/28/2012 |
| Smad2 and PEA3 regulate RGC-32 transcription which is essential for smooth muscle cell differentiation from neural crest cells. | Smad2 and PEA3 cooperatively regulate transcription of response gene to complement 32 in TGF-β-induced smooth muscle cell differentiation of neural crest cells.
Huang WY, Xie W, Guo X, Li F, Jose PA, Chen SY., Free PMC Article | 10/8/2011 |