| Effects of aerobic exercise on the regulation of mitochondrial carrier homolog-2 and its influence on the catabolic and anabolic activity of lipids in the mesenteric adipose tissue of obese mice. | Effects of aerobic exercise on the regulation of mitochondrial carrier homolog-2 and its influence on the catabolic and anabolic activity of lipids in the mesenteric adipose tissue of obese mice.
de Melo DG, da Cruz Rodrigues VC, de Sá Pereira GJ, de Campos TDP, Dos Santos Canciglieri R, Pauli JR, da Silva ASR, da Costa Fernandes CJ, de Moura LP. | 04/26/2024 |
| Silica nanoparticles inducing the apoptosis via microRNA-450b-3p targeting MTCH2 in mice and spermatocyte cell. | Silica nanoparticles inducing the apoptosis via microRNA-450b-3p targeting MTCH2 in mice and spermatocyte cell.
Zhou G, Liu J, Li X, Sang Y, Zhang Y, Gao L, Wang J, Yu Y, Ge W, Sun Z, Zhou X. | 04/17/2021 |
| Downregulated miR-150 in bone marrow mesenchymal stem cells attenuates the apoptosis of LPS-stimulated RAW264.7 via MTCH2-dependent mitochondria transfer. | Downregulated miR-150 in bone marrow mesenchymal stem cells attenuates the apoptosis of LPS-stimulated RAW264.7 via MTCH2-dependent mitochondria transfer.
Zhou X, Zhang K, He Z, Deng Y, Gao Y. | 12/5/2020 |
| Mitochondrial Carrier Homolog 2 forebrain conditional knockout mice exhibit impaired spatial but not motor learning and an impairment in long-term potentiation in hippocampal slices. | Learning Deficits in Adult Mitochondria Carrier Homolog 2 Forebrain Knockout Mouse.
Aloni E, Ruggiero A, Gross A, Segal M. | 03/2/2019 |
| Mitochondrial carrier homolog 2 protein (MTCH2) knockout (-/-) embryonic stem cells (ESCs) fail to elongate their mitochondria and to alter their metabolism. | MTCH2-mediated mitochondrial fusion drives exit from naïve pluripotency in embryonic stem cells.
Bahat A, Goldman A, Zaltsman Y, Khan DH, Halperin C, Amzallag E, Krupalnik V, Mullokandov M, Silberman A, Erez A, Schimmer AD, Hanna JH, Gross A., Free PMC Article | 01/12/2019 |
| MTCH2 is a critical player in neuronal cell biology, controlling mitochondria metabolism, motility and calcium buffering to regulate hippocampal-dependent cognitive functions. | Loss of forebrain MTCH2 decreases mitochondria motility and calcium handling and impairs hippocampal-dependent cognitive functions.
Ruggiero A, Aloni E, Korkotian E, Zaltsman Y, Oni-Biton E, Kuperman Y, Tsoory M, Shachnai L, Levin-Zaidman S, Brenner O, Segal M, Gross A., Free PMC Article | 11/10/2018 |
| Results show that Mimp/Mtch2 overexpression alters lipid metabolism and may play a role in the onset of obesity and development of insulin resistance. | Mimp/Mtch2, an Obesity Susceptibility Gene, Induces Alteration of Fatty Acid Metabolism in Transgenic Mice.
Bar-Lev Y, Moshitch-Moshkovitz S, Tsarfaty G, Kaufman D, Horev J, Resau JH, Tsarfaty I., Free PMC Article | 07/22/2017 |
| MTCH2 is a conserved regulator of lipid homeostasis. MTCH2 was found to be both required and sufficient for lipid homeostasis shifts, suggesting that pharmacological inhibition of MTCH2 could be therapeutic for treatment of obesity and related disorders. MTCH2 could influence lipid homeostasis through inhibition of ESR1 activity. | MTCH2 is a conserved regulator of lipid homeostasis.
Rottiers V, Francisco A, Platov M, Zaltsman Y, Ruggiero A, Lee SS, Gross A, Libert S. | 07/8/2017 |
| Loss of MTCH2 increases muscle metabolism, energy expenditure, heart function, and protects from diet-induced obesity. | Loss of Muscle MTCH2 Increases Whole-Body Energy Utilization and Protects from Diet-Induced Obesity.
Buzaglo-Azriel L, Kuperman Y, Tsoory M, Zaltsman Y, Shachnai L, Zaidman SL, Bassat E, Michailovici I, Sarver A, Tzahor E, Haran M, Vernochet C, Gross A. | 11/12/2016 |
| Loss of Mtch2 increases mitochondrial OXPHOS, triggering HSC entry into cycle. Elevated OXPHOS is accompanied by an increase in mitochondrial size, increase in ATP and ROS levels, and protection from irradiation-induced apoptosis. | An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate.
Maryanovich M, Zaltsman Y, Ruggiero A, Goldman A, Shachnai L, Zaidman SL, Porat Z, Golan K, Lapidot T, Gross A. | 04/16/2016 |
| Data indicate that Mtch2 accelerated conformational change in membrane-bound tBid (Bid) enables it to activate Bax. | tBid undergoes multiple conformational changes at the membrane required for Bax activation.
Shamas-Din A, Bindner S, Zhu W, Zaltsman Y, Campbell C, Gross A, Leber B, Andrews DW, Fradin C., Free PMC Article | 11/16/2013 |