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    Cxcl11 chemokine (C-X-C motif) ligand 11 [ Mus musculus (house mouse) ]

    Gene ID: 56066, updated on 30-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Myostatin and CXCL11 promote nervous tissue macrophages to maintain osteoarthritis pain.

    Myostatin and CXCL11 promote nervous tissue macrophages to maintain osteoarthritis pain.
    Martin Gil C, Raoof R, Versteeg S, Willemen HLDM, Lafeber FPJG, Mastbergen SC, Eijkelkamp N.

    01/26/2024
    Chemokine redundancy versus specificity in the context of CXCR3 and its ligands.

    Chemokine redundancy versus specificity in the context of CXCR3 and its ligands.
    Ridley AJ, Dyer DP.

    07/16/2022
    CXCL11 expressing C57BL/6 mice have intact adaptive immune responses to viral infection.

    CXCL11 expressing C57BL/6 mice have intact adaptive immune responses to viral infection.
    Dalit L, Alvarado C, Küijper L, Kueh AJ, Weir A, D'Amico A, Herold MJ, Vince JE, Nutt SL, Groom JR., Free PMC Article

    05/7/2022
    Obesity is common in alcoholic hepatitis (AH) and associated with a greater than two-fold increase in short-term mortality. Obese AH is associated with a different inflammatory phenotype, with the greatest elevation in CXCL11

    Obesity in acute alcoholic hepatitis increases morbidity and mortality.
    Parker R, Kim SJ, Im GY, Nahas J, Dhesi B, Vergis N, Sinha A, Ghezzi A, Rink MR, McCune A, Aithal GP, Newsome PN, Weston CJ, Holt A, Gao B., Free PMC Article

    12/21/2019
    although the expression of CXCL9 and CXCL11 are increased after spinal nerve ligation, they may not contribute to the maintenance of neuropathic pain.

    Spinal CXCL9 and CXCL11 are not involved in neuropathic pain despite an upregulation in the spinal cord following spinal nerve injury.
    Wu XB, He LN, Jiang BC, Shi H, Bai XQ, Zhang WW, Gao YJ., Free PMC Article

    10/27/2018
    These findings functionally integrate K17, hnRNP K, and gene expression along with RSK and CXCR3 signaling in a keratinocyte-autonomous axis and provide a potential basis for their implication in tumorigenesis

    Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes.
    Chung BM, Arutyunov A, Ilagan E, Yao N, Wills-Karp M, Coulombe PA., Free PMC Article

    05/2/2015
    very low doses of CXCL11 rapidly suppress signs of EAE in C57BL/6 mice lacking functional CXCL11.

    CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis.
    Zohar Y, Wildbaum G, Novak R, Salzman AL, Thelen M, Alon R, Barsheshet Y, Karp CL, Karin N., Free PMC Article

    06/21/2014
    Data indicate that epidermis-derived I-TAC (Cxcl11) triggers a sustained Th2-response that determines the outcome of a complex immunological process.

    Epidermal expression of I-TAC (Cxcl11) instructs adaptive Th2-type immunity.
    Roebrock K, Sunderkötter C, Münck NA, Wolf M, Nippe N, Barczyk K, Varga G, Vogl T, Roth J, Ehrchen J.

    06/7/2014
    Analysis of genes within the Listr1 locus identified a frameshift mutation in the Cxcl11 gene of the C57BL/6 strain that prevents production of the mature chemokine CXCL11.

    Listr1 locus regulates innate immunity against Listeria monocytogenes infection in the mouse liver possibly through Cxcl11 polymorphism.
    Qi Z, Wang J, Han X, Yang J, Zhao G, Cao Y.

    05/17/2014
    Cxcl10 and cxcl11 are new hair-specific transcriptional targets of ectodysplasin, and they indicates involvement of chemokines in hair development.

    Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development.
    Lefebvre S, Fliniaux I, Schneider P, Mikkola ML.

    05/26/2012
    the CXCL11-heparin interaction has two different affinities for glycosaminoglycans

    Characterization of the chemokine CXCL11-heparin interaction suggests two different affinities for glycosaminoglycans.
    Severin IC, Gaudry JP, Johnson Z, Kungl A, Jansma A, Gesslbauer B, Mulloy B, Power C, Proudfoot AE, Handel T., Free PMC Article

    06/28/2010
    Acute ethanol intoxication impairs lung expression of Cxcl11, interfering with pulmonary response to bacterial challenge.

    Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharide.
    Happel KI, Rudner X, Quinton LJ, Movassaghi JL, Clark C, Odden AR, Zhang P, Bagby GJ, Nelson S, Shellito JE., Free PMC Article

    01/21/2010
    I-TAC can have an important role during virus infections and vaccinia virus has evolved ways to avoid inducing I-TAC expression.

    A recombinant vaccinia virus encoding the interferon-inducible T-cell alpha chemoattractant is attenuated in vivo.
    Hamilton NH, Mahalingam S, Banyer JL, Ramshaw IA, Thomson SA.

    01/21/2010
    I-TAC acts as an antagonist for CCR5. I-TAC inhibited the binding of macrophage-inflammatory protein-1alpha (MIP-1alpha)/CC chemokine ligand 3 (CCL3) to cells transfected with CCR5 and to monocytes.

    I-TAC/CXCL11 is a natural antagonist for CCR5.
    Petkovic V, Moghini C, Paoletti S, Uguccioni M, Gerber B.

    01/21/2010
    CXCL11 gene induction by interferon is STAT3 dependent

    Identification of CXCL11 as a STAT3-dependent gene induced by IFN.
    Yang CH, Wei L, Pfeffer SR, Du Z, Murti A, Valentine WJ, Zheng Y, Pfeffer LM.

    01/21/2010
    homologous to human T cell attracting chemokine CXC receptor ligand 11; involved in calcium mobilization and chemotaxis

    Cross reactivity of three T cell attracting murine chemokines stimulating the CXC chemokine receptor CXCR3 and their induction in cultured cells and during allograft rejection.
    Meyer M, Hensbergen PJ, van der Raaij-Helmer EM, Brandacher G, Margreiter R, Heufler C, Koch F, Narumi S, Werner ER, Colvin R, Luster AD, Tensen CP, Werner-Felmayer G.

    09/26/2001
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