| Sphincter of Oddi Dysfunction Induces Gallstone by Inhibiting the Expression of ABCB11 via PKC-alpha. | Sphincter of Oddi Dysfunction Induces Gallstone by Inhibiting the Expression of ABCB11 via PKC-α.
Zhu L, Su W, Xu X, Shao S, Qin C, Gao R, Wang X, Ma M, Gao J, Zhang Z. | 09/23/2024 |
| Cav-1 regulates the bile salt export pump on the canalicular membrane of hepatocytes by PKCalpha-associated signalling under cholesterol stimulation. | Cav-1 regulates the bile salt export pump on the canalicular membrane of hepatocytes by PKCα-associated signalling under cholesterol stimulation.
Pang L, Cui M, Wu S, Kong J., Free PMC Article | 02/9/2024 |
| An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets. | An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets.
Keller MP, Hawes EM, Schueler KL, Stapleton DS, Mitok KA, Simonett SP, Oeser JK, Sampson LL, Attie AD, Magnuson MA, O'Brien RM., | 02/1/2024 |
| Bsep/Abcb11 knockout ameliorates Schistosoma mansoni liver pathology by reducing parasite fecundity. | Bsep/Abcb11 knockout ameliorates Schistosoma mansoni liver pathology by reducing parasite fecundity.
Macháček T, Fuchs CD, Winkelmann F, Frank M, Scharnagl H, Stojakovic T, Sombetzki M, Trauner M., Free PMC Article | 11/1/2023 |
| miR-199a-5p inhibits the expression of ABCB11 in obstructive cholestasis. | miR-199a-5p inhibits the expression of ABCB11 in obstructive cholestasis.
Balasubramaniyan N, Devereaux MW, Orlicky DJ, Sokol RJ, Suchy FJ., Free PMC Article | 01/29/2022 |
| Absence of Bsep/Abcb11 attenuates MCD diet-induced hepatic steatosis but aggravates inflammation in mice. | Absence of Bsep/Abcb11 attenuates MCD diet-induced hepatic steatosis but aggravates inflammation in mice.
Fuchs CD, Krivanec S, Steinacher D, Mlitz V, Wahlström A, Stahlman M, Claudel T, Scharnagl H, Stojakovic T, Marschall HU, Trauner M., Free PMC Article | 08/28/2021 |
| Tanshinone IIA prevents rifampicin-induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2. | Tanshinone IIA prevents rifampicin-induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2.
Yang Y, Liu L, Zhang X, Jiang X, Wang L. | 03/27/2021 |
| Heterozygous knockout of Bile salt export pump ameliorates liver steatosis in mice fed a high-fat diet. | Heterozygous knockout of Bile salt export pump ameliorates liver steatosis in mice fed a high-fat diet.
Okushin K, Tsutsumi T, Ikeuchi K, Kado A, Enooku K, Fujinaga H, Yamauchi N, Ushiku T, Moriya K, Yotsuyanagi H, Koike K., Free PMC Article | 10/3/2020 |
| Studied effect of endotoxin exposure on liver following partial hepatectomy; found endotoxin exposure induced autoantibody production against Bsep (bile salt export pump) leading to dysfunction of hepatobiliary transporter systems. | De Novo Endotoxin-Induced Production of Antibodies against the Bile Salt Export Pump Associated with Bacterial Infection following Major Hepatectomy.
Chan KM, Cheng CH, Wu TH, Lee CF, Wu TJ, Chou HS, Lee WC., Free PMC Article | 10/6/2018 |
| Isoniazid/rifampicin administration significantly down-regulated the expression of hepatic bile acids transporters Ntcp and Bsep in liver. | The inhibition of hepatic bile acids transporters Ntcp and Bsep is involved in the pathogenesis of isoniazid/rifampicin-induced hepatotoxicity.
Guo YX, Xu XF, Zhang QZ, Li C, Deng Y, Jiang P, He LY, Peng WX. | 07/16/2016 |
| mechanism of increased biliary lipid secretion in Bsep-/- mice is based on increased expression of the responsible canalicular transporter proteins. | The mechanism of increased biliary lipid secretion in mice with genetic inactivation of bile salt export pump.
Gooijert KE, Havinga R, Wolters H, Wang R, Ling V, Tazuma S, Verkade HJ. | 05/2/2015 |
| expression repressed by estradiol in the late stages of pregnancy | Transcriptional dynamics of bile salt export pump during pregnancy: mechanisms and implications in intrahepatic cholestasis of pregnancy.
Song X, Vasilenko A, Chen Y, Valanejad L, Verma R, Yan B, Deng R., Free PMC Article | 02/14/2015 |
| LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes. | LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes.
Homolya L, Fu D, Sengupta P, Jarnik M, Gillet JP, Vitale-Cross L, Gutkind JS, Lippincott-Schwartz J, Arias IM., Free PMC Article | 01/3/2015 |
| CA feeding of Bsep (-/-) mice increased hepatic Cyp3a11 protein levels. | Hepatic bile acid metabolism and expression of cytochrome P450 and related enzymes are altered in Bsep (-/-) mice.
Hrycay E, Forrest D, Liu L, Wang R, Tai J, Deo A, Ling V, Bandiera S. | 11/8/2014 |
| FXR regulates BSEP in an isoform-dependent and species-specific manner | Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor.
Song X, Chen Y, Valanejad L, Kaimal R, Yan B, Stoner M, Deng R., Free PMC Article | 05/17/2014 |
| Ursodeoxycholic acid fed to abcb11-/- mice caused liver damage and the appearance of biliary tetra- and penta-hydroxy bile acids. | Defective canalicular transport and toxicity of dietary ursodeoxycholic acid in the abcb11-/- mouse: transport and gene expression studies.
Wang R, Liu L, Sheps JA, Forrest D, Hofmann AF, Hagey LR, Ling V. | 11/2/2013 |
| Hepatic Abcb11 overexpression in mice increases the conservation of bile acids within the enterohepatic circulation. | Hepatic overexpression of Abcb11 in mice promotes the conservation of bile acids within the enterohepatic circulation.
Henkel AS, Gooijert KE, Havinga R, Boverhof R, Green RM, Verkade HJ., Free PMC Article | 03/9/2013 |
| The authors show that two of these transporters, ABCB11 and ATP8B1, are functional targets of miR-33, a micro-RNA that is expressed from within an intron of SREBP-2. | miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity.
Allen RM, Marquart TJ, Albert CJ, Suchy FJ, Wang DQ, Ananthanarayanan M, Ford DA, Baldán A., Free PMC Article | 01/26/2013 |
| Abcb11 deficiency induces cholestasis coupled to impaired beta-fatty acid oxidation in mice. | Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice.
Zhang Y, Li F, Patterson AD, Wang Y, Krausz KW, Neale G, Thomas S, Nachagari D, Vogel P, Vore M, Gonzalez FJ, Schuetz JD., Free PMC Article | 09/29/2012 |
| hyperosmotic cholestasis is triggered by a NADPH oxidase-driven reactive oxygen species formation that mediates Fyn-dependent retrieval of the Mrp2 and Bsep from the canalicular membrane, which may involve an increased cortactin phosphorylation. | The Src family kinase Fyn mediates hyperosmolarity-induced Mrp2 and Bsep retrieval from canalicular membrane.
Cantore M, Reinehr R, Sommerfeld A, Becker M, Häussinger D., Free PMC Article | 03/3/2012 |
| Hepatic overexpression of Abcb11 in mice promotes diet-induced obesity and hypercholesterolemia; increased intestinal cholesterol absorption by hydrophobic bile acids might cause these features. | Hepatic overexpression of abcb11 promotes hypercholesterolemia and obesity in mice.
Henkel AS, Kavesh MH, Kriss MS, Dewey AM, Rinella ME, Green RM., Free PMC Article | 12/3/2011 |
| bile salt export pump (BSEP) | Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption.
Chopra AR, Kommagani R, Saha P, Louet JF, Salazar C, Song J, Jeong J, Finegold M, Viollet B, DeMayo F, Chan L, Moore DD, O'Malley BW., Free PMC Article | 02/26/2011 |
| triple knockout mouse (Mdr1a & Mdr1b &BSEP) is the most severe genetic model of intrahepatic cholestasis yet developed. P-glycoprotein functions as a critical compensatory mechanism, which reduces the severity of cholestasis in Bsep knockout mice. | Compensatory role of P-glycoproteins in knockout mice lacking the bile salt export pump.
Wang R, Chen HL, Liu L, Sheps JA, Phillips MJ, Ling V. | 01/21/2010 |
| Report Role of hepatic Bsep transporter in prevention of bile acid toxicity after partial hepatectomy in mice. | Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice.
Csanaky IL, Aleksunes LM, Tanaka Y, Klaassen CD., Free PMC Article | 01/21/2010 |
| membrane cholesterol content is a critical determinant of ABCB11/ABCC2 transport activity, which might provide an explanation for the etiology of ATP8B1 disease | Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content.
Paulusma CC, de Waart DR, Kunne C, Mok KS, Elferink RP., Free PMC Article | 01/21/2010 |