| IGF-II increased BSP transcription by targeting CRE, FRE and HOX elements in the proximal promoter of the rat BSP gene. Moreover, phospho-CREB1, c-Fos, c-Jun, Dlx5 and Runx2 transcription factors appear to be key regulators of IGF-II effects on BSP transcription. | Insulin-like growth factor-II regulates bone sialoprotein gene transcription.
Choe J, Sasaki Y, Zhou L, Takai H, Nakayama Y, Ogata Y. | 08/26/2017 |
| ERalpha stimulates BSP gene transcription in a ligand-independent manner by targeting the cAMP response element and AP1/glucocorticoid response elements in the rat BSP gene promoter. | Unliganded estrogen receptor α stimulates bone sialoprotein gene expression.
Takai H, Matsumura H, Matsui S, Kim KM, Mezawa M, Nakayama Y, Ogata Y. | 04/26/2014 |
| Protamine stimulates bone sialoprotein gene expression. | Protamine stimulates bone sialoprotein gene expression.
Zhou L, Matsumura H, Mezawa M, Takai H, Nakayama Y, Mitarai M, Ogata Y. | 03/30/2013 |
| These findings indicate that ET-1 increases BSP transcription via the CRE, FRE and HOX sites in the rat BSP gene promoter. | Endothelin-1 regulates rat bone sialoprotein gene transcription.
Li X, Wang Z, Yang L, Li Z, Ogata Y. | 10/4/2010 |
| These studies demonstrate that SPG25, a polyphosphate stimulates BSP transcription by targeting FRE and HOX elements in the proximal promoter of the rat BSP gene. | Effects of inorganic polyphosphate on bone sialoprotein gene expression.
Wang Z, Li X, Li Z, Yang L, Sasaki Y, Wang S, Zhou L, Araki S, Mezawa M, Takai H, Ogata Y. | 03/8/2010 |
| Upon binding to collagen, rBSP displays an increase in nucleation potency, implying a co-operative effect of BSP and collagen in mineral formation | Bone sialoprotein-collagen interaction promotes hydroxyapatite nucleation.
Baht GS, Hunter GK, Goldberg HA. | 01/21/2010 |
| The orientation of BSP for MC3T3-E1 cell adhesion when it was specifically bound to collagen is examined and compared with OPN. | Adhesion of MC3T3-E1 cells to bone sialoprotein and bone osteopontin specifically bound to collagen I.
Bernards MT, Qin C, Ratner BD, Jiang S., Free PMC Article | 01/21/2010 |
| gene transcription is stimulated by FGF2 by targeting the FRE and AP1/GRE elements in the rat bone sialoprotein gene promoter | AP1 binding site is another target of FGF2 regulation of bone sialoprotein gene transcription.
Takai H, Araki S, Mezawa M, Kim DS, Li X, Yang L, Li Z, Wang Z, Nakayama Y, Ogata Y. | 01/21/2010 |
| Androgen receptor stimulates BSP gene transcription by targeting the cAMP response element (RE) and AP1/glucocorticoid RE elements in the promoter of the rat BSP gene. | Androgen receptor stimulates bone sialoprotein (BSP) gene transcription via cAMP response element and activator protein 1/glucocorticoid response elements.
Takai H, Nakayama Y, Kim DS, Arai M, Araki S, Mezawa M, Nakajima Y, Kato N, Masunaga H, Ogata Y. | 01/21/2010 |
| BSP may serve as a matrix-associated signal directly promoting osteoblast differentiation resulting in the increased production of a mineralized matrix. | Bone sialoprotein expression enhances osteoblast differentiation and matrix mineralization in vitro.
Gordon JA, Tye CE, Sampaio AV, Underhill TM, Hunter GK, Goldberg HA. | 01/21/2010 |
| the precise location and orientation of the CCAAT element is necessary for optimizing basal transcription of the bone sialoprotein gene | Stereochemical analysis of the functional significance of the conserved inverted CCAAT and TATA elements in the rat bone sialoprotein gene promoter.
Su M, Lee D, Ganss B, Sodek J. | 01/21/2010 |
| Results conclude that residues 19-46 of bone sialoprotein represent a novel collagen-binding site. | Identification of the type I collagen-binding domain of bone sialoprotein and characterization of the mechanism of interaction.
Tye CE, Hunter GK, Goldberg HA. | 01/21/2010 |
| A novel FGF2 response element within the proximal promoter of the BSP gene that mediates both constitutive and FGF2-induced BSP transcription has been identified. | Identification of FGF2-response element in the rat bone sialoprotein gene promoter.
Shimizu-Sasaki E, Yamazaki M, Furuyama S, Sugiya H, Sodek J, Ogata Y. | 01/21/2010 |
| These studies, therefore, show that chlorpromazine suppresses BSP gene transcription through tyrosine and MAP kinases-dependent pathways and that the chlorpromazine effects are mediated by CRE and FRE elements in the proximal promoter of the BSP gene | Effect of chlorpromazine on bone sialoprotein (BSP) gene transcription.
Nakajima Y, Kato N, Nakayama Y, Kim DS, Takai H, Arai M, Saito R, Samoto H, Shimizu E, Ogata Y. | 01/21/2010 |
| delineation of the hydroxyapatite-nucleating domains | Delineation of the hydroxyapatite-nucleating domains of bone sialoprotein.
Tye CE, Rattray KR, Warner KJ, Gordon JA, Sodek J, Hunter GK, Goldberg HA. | 01/21/2010 |
| Activation of bone sialoprotein gene transcription by flavonoids is mediated through an inverted CCAAT box in ROS 17/2.8 cells | Activation of bone sialoprotein gene transcription by flavonoids is mediated through an inverted CCAAT box in ROS 17/2.8 cells.
Shimizu E, Ogata Y. | 01/21/2010 |
| Data show that RUNX2 is a direct regulator of bone sialoprotein in osteoblasts and that it functions in cooperation with DLX5 or a related factor to activate osteoblast-specific gene expression. | Cooperative interactions between RUNX2 and homeodomain protein-binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene.
Roca H, Phimphilai M, Gopalakrishnan R, Xiao G, Franceschi RT. | 01/21/2010 |
| c-Jun and E1A regulate basal transcription of bsp in osteosarcoma cells by recruiting the NF-Y transcriptional complex to the ICE box in a mechanism that is independent of p300/CBP and P/CAF HAT activities | Recruitment of nuclear factor Y to the inverted CCAAT element (ICE) by c-Jun and E1A stimulates basal transcription of the bone sialoprotein gene in osteosarcoma cells.
Su M, Bansal AK, Mantovani R, Sodek J. | 01/21/2010 |