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    ppan peter pan [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42502, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ppanprovided by FlyBase
    Official Full Name
    peter panprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010770
    Locus tag
    Dmel_CG5786
    See related
    AllianceGenome:FB:FBgn0010770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5786; Dmel\CG5786; l(3)02231; l(3)j6B6; Ppan; PPAN; SSF1
    Summary
    Predicted to enable rRNA binding activity. Involved in female gamete generation; imaginal disc development; and larval development. Predicted to be part of preribosome, large subunit precursor. Is expressed in organism. Orthologous to several human genes including PPAN-P2RY11 (PPAN-P2RY11 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See ppan in Genome Data Viewer
    Location:
    93B13-93B13; 3-70 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21116254..21117899)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16941976..16943621)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene tetracycline resistance Neighboring gene Rab11 Neighboring gene Bride of doubletime Neighboring gene supernumerary limbs Neighboring gene uncharacterized protein Neighboring gene Odorant-binding protein 93a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of peter pan, a novel Drosophila gene required for larval growth. Migeon JC, et al. Mol Biol Cell, 1999 Jun. PMID 10359593, Free PMC Article
    2. The archaeal homolog of the Imp4 protein, a eukaryotic U3 snoRNP component. Mayer C, et al. Trends Biochem Sci, 2001 Mar. PMID 11246005
    3. The Brix domain protein family -- a key to the ribosomal biogenesis pathway? Eisenhaber F, et al. Trends Biochem Sci, 2001 Jun. PMID 11406393
    4. The EGF/Ras pathway controls growth in Drosophila via ribosomal RNA synthesis. Sriskanthadevan-Pirahas S, et al. Dev Biol, 2018 Jul 1. PMID 29660312
    5. Upregulation of ribosome biogenesis via canonical E-boxes is required for Myc-driven proliferation. Zielke N, et al. Dev Cell, 2022 Apr 25. PMID 35472319

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in female gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peter pan
    Names
    CG5786-PA
    peterpan
    ppan-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21116254..21117899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057631.6 → NP_476979.1  peter pan [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476979.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O97133, Q9VDE5
      Related
      FBpp0083415
      Conserved Domains (2) summary
      smart00879
      Location:31 → 212
      Brix; The Brix domain is found in a number of eukaryotic proteins
      cl00935
      Location:215 → 295
      Brix; Brix domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BIK3 Q5BIK3
    Q9VDE5.1 Q9VDE5

    Gene LinkOut

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