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    CAHbeta Carbonic anhydrase beta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41070, updated on 10-May-2024

    Summary

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    Official Symbol
    CAHbetaprovided by FlyBase
    Official Full Name
    Carbonic anhydrase betaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037646
    Locus tag
    Dmel_CG11967
    See related
    AllianceGenome:FB:FBgn0037646
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BCA; beta-CA; CG11967; DmBCA; DmeCA; Dmel\CG11967; Dmel_CG11967
    Summary
    Enables carbonate dehydratase activity. Involved in one-carbon metabolic process. Located in mitochondrion. Is expressed in adult heart and organism. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    85C1-85C1; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8980860..8982793)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4806582..4808515)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Succinyl-coenzyme A synthetase beta subunit, ADP-forming Neighboring gene uncharacterized protein Neighboring gene ichor Neighboring gene Ras-related GTP binding A/B Neighboring gene uncharacterized protein Neighboring gene Enhancer of variegation 3-9 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bortezomib inhibits bacterial and fungal β-carbonic anhydrases. Supuran CT. Bioorg Med Chem, 2016 Sep 15. PMID 27469982
    2. β carbonic anhydrase is required for female fertility in Drosophila melanogaster. Syrjänen L, et al. Front Zool, 2015. PMID 26300950, Free PMC Article
    3. Sulfonamide inhibition studies of the β carbonic anhydrase from Drosophila melanogaster. Syrjänen L, et al. Bioorg Med Chem Lett, 2014 Jul 1. PMID 24852120
    4. Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates. Syrjänen L, et al. BMC Biochem, 2010 Jul 26. PMID 20659325, Free PMC Article
    5. Characterization, bioinformatic analysis and dithiocarbamate inhibition studies of two new α-carbonic anhydrases, CAH1 and CAH2, from the fruit fly Drosophila melanogaster. Syrjänen L, et al. Bioorg Med Chem, 2013 Mar 15. PMID 22989910

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in one-carbon metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    carbonic anhydrase beta
    Names
    CAHbeta-PA
    CAHbeta-PB
    CG11967-PA
    CG11967-PB
    GH10821P
    beta-carbonic anhydrase
    NP_001287242.1
    NP_649849.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8980860..8982793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300313.1 → NP_001287242.1  carbonic anhydrase beta, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287242.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGX6
      Conserved Domains (1) summary
      cl00391
      Location:7 → 59
      beta_CA; Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an ...

    2. NM_141592.3 → NP_649849.1  carbonic anhydrase beta, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649849.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHJ5
      Related
      FBpp0081438
      Conserved Domains (1) summary
      cd00884
      Location:7 → 228
      beta_CA_cladeB; Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGX6 A0A0B4LGX6
    Q8SXB6 Q8SXB6
    Q9VHJ5 Q9VHJ5

    Gene LinkOut

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