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    CG12896 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36101, updated on 26-Apr-2024

    Summary

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    Official Symbol
    CG12896provided by FlyBase
    Primary source
    FLYBASE:FBgn0033521
    Locus tag
    Dmel_CG12896
    See related
    AllianceGenome:FB:FBgn0033521
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD11278; Dmel\CG12896; Prx12896; RE05501p; RH54193
    Summary
    Predicted to enable peroxidase activity. Involved in mesoderm development. Predicted to be located in cytoplasm and extracellular exosome. Predicted to be active in cytosol and mitochondrion. Is expressed in organism. Orthologous to human PRDX6 (peroxiredoxin 6). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    47A7-47A7; 2-62 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10426880..10427915, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6314385..6315420, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Peroxiredoxin 6b Neighboring gene Ran-binding protein M Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila gene RanBPM functions in the mushroom body to regulate larval behavior. Scantlebury N, et al. PLoS One, 2010 May 14. PMID 20498842, Free PMC Article
    2. The peroxiredoxin gene family in Drosophila melanogaster. Radyuk SN, et al. Free Radic Biol Med, 2001 Nov 1. PMID 11677042
    3. Peroxiredoxins are conserved markers of circadian rhythms. Edgar RS, et al. Nature, 2012 May 16. PMID 22622569, Free PMC Article
    4. Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation. Gilchrist DA, et al. Cell, 2010 Nov 12. PMID 21074046, Free PMC Article
    5. Transcriptomic analysis provides insights on hexavalent chromium induced DNA double strand breaks and their possible repair in midgut cells of Drosophila melanogaster larvae. Mishra M, et al. Mutat Res, 2013 Jul-Aug. PMID 23628323

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables antioxidant activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peroxiredoxin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thioredoxin peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mesoderm development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    AOP2-related
    CG12896-PA
    NP_610584.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10426880..10427915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136740.4 → NP_610584.2  uncharacterized protein Dmel_CG12896 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610584.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z893, Q9GPQ0, Q9GPQ1
      Related
      FBpp0087406
      Conserved Domains (2) summary
      COG0450
      Location:1 → 194
      AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
      cd03016
      Location:3 → 218
      PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z893 A1Z893
    Q8SY26 Q8SY26

    Gene LinkOut

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