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    Rrm2b ribonucleotide reductase M2 B (TP53 inducible) [ Mus musculus (house mouse) ]

    Gene ID: 382985, updated on 9-May-2024

    Summary

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    Official Symbol
    Rrm2bprovided by MGI
    Official Full Name
    ribonucleotide reductase M2 B (TP53 inducible)provided by MGI
    Primary source
    MGI:MGI:2155865
    See related
    Ensembl:ENSMUSG00000022292 AllianceGenome:MGI:2155865
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p53R2
    Summary
    Enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Acts upstream of or within several processes, including mitochondrial DNA replication; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and nucleoside phosphate metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 3.1), frontal lobe adult (RPKM 2.6) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 B3.1; 15 15.1 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (37924196..37961562, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (37923952..37961119, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38432 Neighboring gene ribosomal protein S19, pseudogene 5 Neighboring gene predicted gene, 35019 Neighboring gene STARR-positive B cell enhancer ABC_E7364 Neighboring gene STARR-positive B cell enhancer mm9_chr15:37889822-37890123 Neighboring gene STARR-positive B cell enhancer ABC_E9416 Neighboring gene 60S ribosomal protein L23a pseudogene Neighboring gene predicted gene, 49085 Neighboring gene ubiquitin protein ligase E3 component n-recognin 5 Neighboring gene STARR-seq mESC enhancer starr_38435 Neighboring gene STARR-seq mESC enhancer starr_38437 Neighboring gene predicted gene, 22353 Neighboring gene predicted gene, 35081

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ribonucleotide reductase: In-vitro S-glutathionylation of R2 and p53R2 subunits of mammalian class I ribonucleotide reductase protein. Chatterji A, et al. Mol Biol Rep, 2021 Nov. PMID 34599703
    2. Rrm2b deletion causes mitochondrial metabolic defects in renal tubules. Chen YF, et al. Sci Rep, 2019 Sep 13. PMID 31519977, Free PMC Article
    3. Ribonucleotide reductase subunit M2B deficiency leads to mitochondrial permeability transition pore opening and is associated with aggressive clinicopathologic manifestations of breast cancer. Xue L, et al. Am J Transl Res, 2018. PMID 30662615, Free PMC Article
    4. Rapid development of glomerular injury and renal failure in mice lacking p53R2. Powell DR, et al. Pediatr Nephrol, 2005 Mar. PMID 15723268
    5. Chromosomal instability triggered by Rrm2b loss leads to IL-6 secretion and plasmacytic neoplasms. Chang L, et al. Cell Rep, 2013 May 30. PMID 23643536, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ribonucleotide reductase: In-vitro S-glutathionylation of R2 and p53R2 subunits of mammalian class I ribonucleotide reductase protein.
      Title: Ribonucleotide reductase: In-vitro S-glutathionylation of R2 and p53R2 subunits of mammalian class I ribonucleotide reductase protein.
    2. Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.
      Title: Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.
    3. Rrm2b deletion causes mitochondrial metabolic defects in renal tubules.
      Title: Rrm2b deletion causes mitochondrial metabolic defects in renal tubules.
    4. Rrm2b plays a crucial role in maintaining chromosomal stability and preventing chronic-inflammation-associated tumorigenesis.
      Title: Chromosomal instability triggered by Rrm2b loss leads to IL-6 secretion and plasmacytic neoplasms.
    5. Rrm2b deficiency caused higher rates of spontaneous mutation in the kidneys of Rrm2b-/- mice. p53R2 has a pivotal role in maintaining dNTP levels for repair of DNA in resting cells.
      Title: Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 2'-deoxyribonucleotide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA synthesis involved in DNA repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within deoxyribonucleoside triphosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in deoxyribonucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within deoxyribonucleotide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitochondrial DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of G0 to G1 transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of G0 to G1 transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within renal system process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribonucleoside diphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribonucleoside-diphosphate reductase subunit M2 B
    Names
    TP53-inducible ribonucleotide reductase M2 B
    p53-inducible ribonucleotide reductase small subunit 2-like protein
    NP_001343951.1
    NP_001343952.1
    NP_001403475.1
    NP_001403476.1
    NP_001403477.1
    NP_001403478.1
    NP_001403479.1
    NP_001403480.1
    NP_001403481.1
    NP_955770.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357022.2 → NP_001343951.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122291
      UniProtKB/TrEMBL
      D3Z2A4
      Conserved Domains (1) summary
      cl00264
      Location:18 → 337
      Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins

    2. NM_001357023.2 → NP_001343952.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122291
      UniProtKB/TrEMBL
      D3Z2A4
      Conserved Domains (1) summary
      cl00264
      Location:1 → 297
      Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins

    3. NM_001416546.1 → NP_001403475.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122291

    4. NM_001416547.1 → NP_001403476.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122291

    5. NM_001416548.1 → NP_001403477.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC122291

    6. NM_001416549.1 → NP_001403478.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC122291

    7. NM_001416550.1 → NP_001403479.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC122291

    8. NM_001416551.1 → NP_001403480.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC122291

    9. NM_001416552.1 → NP_001403481.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC122291

    10. NM_199476.2 → NP_955770.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 1

      See identical proteins and their annotated locations for NP_955770.1

      Status: VALIDATED

      Source sequence(s)
      AC122291
      Consensus CDS
      CCDS27437.1
      UniProtKB/Swiss-Prot
      Q6PEE3
      UniProtKB/TrEMBL
      D3Z2A4
      Related
      ENSMUSP00000022901.10, ENSMUST00000022901.16
      Conserved Domains (1) summary
      cl00264
      Location:32 → 351
      Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins

    RNA

    1. NR_184224.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122291

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      37924196..37961562 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PEE3.1 GenPept UniProtKB/Swiss-Prot:Q6PEE3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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