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    CHGB chromogranin B [ Homo sapiens (human) ]

    Gene ID: 1114, updated on 17-Jun-2024

    Summary

    Official Symbol
    CHGBprovided by HGNC
    Official Full Name
    chromogranin Bprovided by HGNC
    Primary source
    HGNC:HGNC:1930
    See related
    Ensembl:ENSG00000089199 MIM:118920; AllianceGenome:HGNC:1930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCG1
    Summary
    This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]
    Expression
    Biased expression in adrenal (RPKM 1898.3) and stomach (RPKM 91.0) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CHGB in Genome Data Viewer
    Location:
    20p12.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (5911510..5925353)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (5951841..5965685)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (5892156..5905999)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17529 Neighboring gene shieldin complex subunit 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17531 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:5807499-5808000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17532 Neighboring gene MPRA-validated peak4135 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr20:5872947-5873157 Neighboring gene RNA, U1 small nuclear 55, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12659 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:5904456-5905655 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12660 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:5920579-5920767 Neighboring gene KN motif and ankyrin repeat domains 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17533 Neighboring gene tRNA methyltransferase 6 non-catalytic subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables hormone activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in secretory granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    secretogranin-1
    Names
    cgB
    secretogranin B
    secretogranin I
    sgI

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042285.1 RefSeqGene

      Range
      5183..19026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001819.3NP_001810.2  secretogranin-1 precursor

      See identical proteins and their annotated locations for NP_001810.2

      Status: REVIEWED

      Source sequence(s)
      BC000375, BM681923, BP422638, DC312240
      Consensus CDS
      CCDS13092.1
      UniProtKB/Swiss-Prot
      A8K021, P05060, Q59EU9, Q6IBS6, Q9BQV6, Q9UC25, Q9UJA6
      UniProtKB/TrEMBL
      B2R5M3
      Related
      ENSP00000368244.4, ENST00000378961.9
      Conserved Domains (1) summary
      pfam01271
      Location:26674
      Granin; Granin (chromogranin or secretogranin)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      5911510..5925353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      5951841..5965685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)