dph6 diphthamine biosynthesis 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dph6provided by ZNC
Official Full Name: diphthamine biosynthesis 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-050227-15
See related: Ensembl:ENSDARG00000042839 AllianceGenome:ZFIN:ZDB-GENE-050227-15
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: atpbd4; wu:fc57a01; zgc:110758; si:ch1073-258j7.1
Summary: Predicted to enable diphthine-ammonia ligase activity. Predicted to be involved in peptidyl-diphthamide biosynthetic process from peptidyl-histidine. Is expressed in female organism. Orthologous to human DPH6 (diphthamine biosynthesis 6). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (53156608..53228826)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (53068663..53143560)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables diphthine-ammonia ligase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein histidyl modification to diphthamide	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: diphthine--ammonia ligase

Names: ATP binding domain 4; ATP-binding domain-containing protein 4; DPH6 homolog; diphthamide synthase; diphthamide synthetase; protein DPH6 homolog

NP_001013308.2

EC 6.3.1.14

XP_017207121.2

EC 6.3.1.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013290.2 → NP_001013308.2 diphthine--ammonia ligase

See identical proteins and their annotated locations for NP_001013308.2

Status: PROVISIONAL

Source sequence(s)

BC133118

UniProtKB/Swiss-Prot

A2RV01, Q5EAS1

Related

ENSDARP00000129691.1, ENSDART00000156774.2

Conserved Domains (1) summary

cd01994
Location:2 → 214

Alpha_ANH_like_IV; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

53156608..53228826

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017351632.2 → XP_017207121.2 diphthine--ammonia ligase isoform X1

UniProtKB/TrEMBL

A0A8M6YVL6

Conserved Domains (3) summary

cd06155
Location:314 → 405

eu_AANH_C_1; A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these ...

cd06156
Location:448 → 554

eu_AANH_C_2; A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these ...

cd01994
Location:2 → 214

Alpha_ANH_like_IV; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...