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    kuk kugelkern [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42063, updated on 26-Apr-2024

    Summary

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    Official Symbol
    kukprovided by FlyBase
    Official Full Name
    kugelkernprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038476
    Locus tag
    Dmel_CG5175
    See related
    AllianceGenome:FB:FBgn0038476
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5175; char; Dmel\CG5175; Kuk; kuk/char
    Summary
    Involved in several processes, including adult locomotory behavior; cell aging; and cellularization. Located in nuclear inner membrane. Is expressed in several structures, including ectoderm; embryonic brain; embryonic/larval nervous system; epithelium; and extended germ band embryo. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    89E12-89E12; 3-59 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17080244..17084781)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12905966..12910503)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S11 Neighboring gene Keap1 Neighboring gene Germinal centre kinase III Neighboring gene chromosome alignment defect 1 Neighboring gene cheerio

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Determining nuclear shape: the role of farnesylated nuclear membrane proteins. Polychronidou M, et al. Nucleus, 2011 Jan-Feb. PMID 21647295, Free PMC Article
    2. Loss of Gα12/13 exacerbates apical area dependence of actomyosin contractility. Xie S, et al. Mol Biol Cell, 2016 Nov 7. PMID 27489340, Free PMC Article
    3. Farnesylated nuclear proteins Kugelkern and lamin Dm0 affect nuclear morphology by directly interacting with the nuclear membrane. Polychronidou M, et al. Mol Biol Cell, 2010 Oct 1. PMID 20685963, Free PMC Article
    4. The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes in Drosophila flies. Brandt A, et al. Aging Cell, 2008 Aug. PMID 18494863
    5. Nuclear morphology: when round kernels do the Charleston. Melcer S, et al. Curr Biol, 2006 Mar 21. PMID 16546068

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kugelkern and lamin Dm0 affect nuclear shape without requiring filament formation or the presence of a classical nuclear lamina.
      Title: Farnesylated nuclear proteins Kugelkern and lamin Dm0 affect nuclear morphology by directly interacting with the nuclear membrane.
    2. Induced expression of the farnesylated lamina proteins Lamin B and Kugelkern cause aberrant nuclear shapes and reduce the lifespan of adult flies.
      Title: The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes in Drosophila flies.
    3. Kugelkern encodes a coiled-coil protein with nuclear localization signal and CxxM motif and is required for nuclear elongation.
      Title: Developmental control of nuclear size and shape by Kugelkern and Kurzkern.
    4. Char is lipid anchored at the nuclear envelope by a farnesylation group, and localises at the inner nuclear membrane. Char forms a scaffold that regulates nuclear architecture to constrain nuclei in tight columnar epithelial cells.
      Title: Developmental control of nuclear morphogenesis and anchoring by charleston, identified in a functional genomic screen of Drosophila cellularisation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cellularization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kugelkern
    Names
    CG5175-PA
    CG5175-PB
    CG5175-PC
    Kugelkern/Charleston
    charleston
    kugelkem
    kuk-PA
    kuk-PB
    kuk-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17080244..17084781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142338.3 → NP_650595.1  kugelkern, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650595.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DML4, Q8SX89, Q9VEN4
      Related
      FBpp0082838
      Conserved Domains (1) summary
      pfam10243
      Location:95 → 290
      MIP-T3; Microtubule-binding protein MIP-T3

    2. NM_001260219.1 → NP_001247148.1  kugelkern, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247148.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DML4, Q8SX89, Q9VEN4
      Conserved Domains (1) summary
      pfam10243
      Location:95 → 290
      MIP-T3; Microtubule-binding protein MIP-T3

    3. NM_169745.3 → NP_732204.1  kugelkern, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732204.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DML4, Q8SX89, Q9VEN4
      Related
      FBpp0082839
      Conserved Domains (1) summary
      pfam10243
      Location:95 → 290
      MIP-T3; Microtubule-binding protein MIP-T3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SX89 Q8SX89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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