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    ZDHHC11B zinc finger DHHC-type containing 11B [ Homo sapiens (human) ]

    Gene ID: 653082, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZDHHC11Bprovided by HGNC
    Official Full Name
    zinc finger DHHC-type containing 11Bprovided by HGNC
    Primary source
    HGNC:HGNC:32962
    See related
    Ensembl:ENSG00000206077 AllianceGenome:HGNC:32962
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DHHC-11B
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in several processes, including antiviral innate immune response; peptidyl-L-cysteine S-palmitoylation; and positive regulation of defense response to virus by host. Predicted to be located in endosome membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung (RPKM 4.3), brain (RPKM 3.1) and 23 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    5p15.33
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (710355..784729, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (710470..784844, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:612309-613238 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:618691-619890 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86736 Neighboring gene centrosomal protein 72 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:643172-643672 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86741 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:643673-644173 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86745 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86749/86750 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86753 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86779 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86783 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:669166-669920 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86803 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86807 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86811 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:673521-674090 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86819 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_86823 and experimental_86827 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86831 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86835 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86841/86842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:686929-687430 Neighboring gene tubulin polymerization promoting protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:692893-693475 Neighboring gene uncharacterized LOC101929898 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15876 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:694389-695267 Neighboring gene NANOG hESC enhancer GRCh37_chr5:708729-709282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:727349-727849 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:752062-752252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:753615-754114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22301 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:758511-759354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:759355-760198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:771879-772522 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:782879-783538 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:785123-785861 Neighboring gene bromodomain containing 9 pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:794321-795181 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:811555-811724 Neighboring gene zinc finger DHHC-type containing 11 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:827809-828355 Neighboring gene signal peptidase complex subunit 2 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:849793-850444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:850445-851094 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:892285-892917 Neighboring gene bromodomain containing 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma. Dzikiewicz-Krawczyk A, et al. Leukemia, 2017 Jun. PMID 28331227
    2. SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair. Zhang H, et al. Nucleic Acids Res, 2019 Nov 4. PMID 31495888, Free PMC Article
    3. The DNA sequence and comparative analysis of human chromosome 5. Schmutz J, et al. Nature, 2004 Sep 16. PMID 15372022
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZDHHC11B is decreased in lung adenocarcinoma and inhibits tumorigenesis via regulating epithelial-mesenchymal transition.
      Title: ZDHHC11B is decreased in lung adenocarcinoma and inhibits tumorigenesis via regulating epithelial-mesenchymal transition.
    2. First, MYC downregulates miR-150 to unleash MYB from the miR-150-mediated repression. Second, MYC induces ZDHHC11 and ZDHHC11B that further ensures the maintenance of high MYB levels
      Title: ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-L-cysteine S-palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable palmitoyltransferase ZDHHC11B
    Names
    zinc finger DHHC domain-containing protein 11B
    NP_001338232.1
    XP_016865599.1
    XP_016865600.1
    XP_016865601.1
    XP_016865602.1
    XP_016865603.1
    XP_016865604.1
    XP_016865605.1
    XP_016865606.1
    XP_016865607.1
    XP_016865608.1
    XP_016865610.1
    XP_024301956.1
    XP_047273536.1
    XP_047273538.1
    XP_047273539.1
    XP_047273540.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001351303.2 → NP_001338232.1  probable palmitoyltransferase ZDHHC11B

      Status: VALIDATED

      Source sequence(s)
      AC026740
      Consensus CDS
      CCDS87287.1
      UniProtKB/Swiss-Prot
      A6NHR3, P0C7U3
      Related
      ENSP00000442373.2, ENST00000508859.8
      Conserved Domains (2) summary
      pfam01529
      Location:120 → 274
      zf-DHHC; DHHC palmitoyltransferase
      cl19890
      Location:38 → 190
      zf-DHHC; DHHC palmitoyltransferase

    RNA

    1. NR_147095.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC026740

    2. NR_147096.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC026740

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      710355..784729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010111.2 → XP_016865600.1  probable palmitoyltransferase ZDHHC11B isoform X1

    2. XM_017010110.2 → XP_016865599.1  probable palmitoyltransferase ZDHHC11B isoform X1

    3. XM_017010115.3 → XP_016865604.1  probable palmitoyltransferase ZDHHC11B isoform X1

    4. XM_017010113.3 → XP_016865602.1  probable palmitoyltransferase ZDHHC11B isoform X1

    5. XM_017010114.3 → XP_016865603.1  probable palmitoyltransferase ZDHHC11B isoform X1

    6. XM_017010112.2 → XP_016865601.1  probable palmitoyltransferase ZDHHC11B isoform X1

    7. XM_017010117.2 → XP_016865606.1  probable palmitoyltransferase ZDHHC11B isoform X4

    8. XM_017010116.3 → XP_016865605.1  probable palmitoyltransferase ZDHHC11B isoform X3

      Conserved Domains (1) summary
      pfam01529
      Location:193 → 329
      zf-DHHC; DHHC palmitoyltransferase

    9. XM_047417580.1 → XP_047273536.1  probable palmitoyltransferase ZDHHC11B isoform X2

    10. XM_024446188.1 → XP_024301956.1  probable palmitoyltransferase ZDHHC11B isoform X2

      Conserved Domains (1) summary
      pfam01529
      Location:193 → 329
      zf-DHHC; DHHC palmitoyltransferase

    11. XM_017010118.1 → XP_016865607.1  probable palmitoyltransferase ZDHHC11B isoform X5

    12. XM_017010119.1 → XP_016865608.1  probable palmitoyltransferase ZDHHC11B isoform X6

    13. XM_047417582.1 → XP_047273538.1  probable palmitoyltransferase ZDHHC11B isoform X8

    14. XM_017010121.1 → XP_016865610.1  probable palmitoyltransferase ZDHHC11B isoform X7

      Conserved Domains (1) summary
      cl19890
      Location:193 → 265
      zf-DHHC; DHHC palmitoyltransferase

    15. XM_047417584.1 → XP_047273540.1  probable palmitoyltransferase ZDHHC11B isoform X10

    16. XM_047417583.1 → XP_047273539.1  probable palmitoyltransferase ZDHHC11B isoform X9

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C7U3.1 GenPept UniProtKB/Swiss-Prot:P0C7U3

    Gene LinkOut

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