RN7SL3 RNA component of signal recognition particle 7SL3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RN7SL3provided by HGNC
Official Full Name: RNA component of signal recognition particle 7SL3provided by HGNC
Primary source: HGNC:HGNC:23135
See related: Ensembl:ENSG00000278771 MIM:612180; AllianceGenome:HGNC:23135
Gene type: scRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: 7L30.2; RNSRP3; RN7SL631P
Summary: The signal recognition particle (SRP) is a cytoplasmic ribonucleoprotein complex that mediates cotranslational insertion of secretory proteins into the lumen of the endoplasmic reticulum. The SRP consists of 6 polypeptides (e.g., SRP19; MIM 182175) and a 7SL RNA molecule, such as RN7SL3, that is partially homologous to Alu DNA (Ullu and Weiner, 1984 [PubMed 6084597]).[supplied by OMIM, Jul 2008]
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Genomic context

Location:: 14q21.3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (49853616..49853914, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (44058839..44059137, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (50320334..50320632, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RN7SL3 is a functional gene with two novelregiulatory sequences: a TATA box and intrnal A and B box-like motifs.
Title: Novel upstream and intragenic control elements for the RNA polymerase III-dependent transcription of human 7SL RNA genes.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Other Names

RNA, 7SL, cytoplasmic 3
RNA, 7SL, cytoplasmic 631, pseudogene
SRP RNA 3

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of signal recognition particle, endoplasmic reticulum targeting	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.