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    Acad8 acyl-CoA dehydrogenase family, member 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367196, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Acad8provided by RGD
    Official Full Name
    acyl-CoA dehydrogenase family, member 8provided by RGD
    Primary source
    RGD:1564209
    See related
    Ensembl:ENSRNOG00000048164 AllianceGenome:RGD:1564209
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564209
    Summary
    Predicted to enable acyl-CoA dehydrogenase activity and flavin adenine dinucleotide binding activity. Orthologous to human ACAD8 (acyl-CoA dehydrogenase family member 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 230.6), Kidney (RPKM 182.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    8q13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (33641420..33665542, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (25382271..25406404, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (28023401..28044967, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene pescadillo ribosomal biogenesis factor 1, pseudogene 5 Neighboring gene beta-galactosidase-like protein Neighboring gene thymocyte nuclear protein 1 Neighboring gene VPS26 retromer complex component B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of isobutyryl-CoA dehydrogenase and its deficiency in humans. Nguyen TV, et al. Mol Genet Metab, 2002 Sep-Oct. PMID 12359132
    2. Comparative studies of Acyl-CoA dehydrogenases for monomethyl branched chain substrates in amino acid metabolism. Liu X, et al. Bioorg Chem, 2013 Apr. PMID 23474214
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Isobutyryl-CoA dehydrogenase did not show the isomerase activity.
      Title: Comparative studies of Acyl-CoA dehydrogenases for monomethyl branched chain substrates in amino acid metabolism.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carboxylic acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    isobutyryl-CoA dehydrogenase, mitochondrial
    NP_001385734.1
    XP_038938216.1
    XP_038938217.1
    XP_038938218.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398805.1 → NP_001385734.1  isobutyryl-CoA dehydrogenase, mitochondrial

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000008
      Related
      ENSRNOP00000080808.1, ENSRNOT00000120030.1
      Conserved Domains (1) summary
      cd01162
      Location:37 → 410
      IBD; Isobutyryl-CoA dehydrogenase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      33641420..33665542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082288.2 → XP_038938216.1  isobutyryl-CoA dehydrogenase, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl09933
      Location:27 → 316
      ACAD; Acyl-CoA dehydrogenase

    2. XM_039082289.2 → XP_038938217.1  isobutyryl-CoA dehydrogenase, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl09933
      Location:1 → 211
      ACAD; Acyl-CoA dehydrogenase

    3. XM_039082290.2 → XP_038938218.1  isobutyryl-CoA dehydrogenase, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl09933
      Location:1 → 211
      ACAD; Acyl-CoA dehydrogenase
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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