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    MT1DP metallothionein 1D, pseudogene [ Homo sapiens (human) ]

    Gene ID: 326343, updated on 23-Nov-2023

    Summary

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    Official Symbol
    MT1DPprovided by HGNC
    Official Full Name
    metallothionein 1D, pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:7396
    See related
    Ensembl:ENSG00000291095 AllianceGenome:HGNC:7396
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MTM
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in cellular response to metal ion; cellular zinc ion homeostasis; and detoxification of copper ion. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    Location:
    16q13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (56643687..56644941)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (62438667..62439921)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (56677599..56678853)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene metallothionein 1J, pseudogene Neighboring gene metallothionein 1A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:56681377-56681944 Neighboring gene metallothionein 1C, pseudogene Neighboring gene metallothionein 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids. Richards RI, et al. Cell, 1984 May. PMID 6327055
    2. Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia. Le Beau MM, et al. Nature, 1985 Feb 21-27. PMID 3856101
    3. Structure and tissue-specific expression of the human metallothionein IB gene. Heguy A, et al. Mol Cell Biol, 1986 Jun. PMID 3785191, Free PMC Article
    4. Tumor suppressor long non-coding RNA, MT1DP is negatively regulated by YAP and Runx2 to inhibit FoxA1 in liver cancer cells. Yu W, et al. Cell Signal, 2014 Dec. PMID 25261601
    5. Human metallothionein genes are clustered on chromosome 16. Karin M, et al. Proc Natl Acad Sci U S A, 1984 Sep. PMID 6089206, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The close relationship between Runx2 and YAP plays a pro-carcinogenetic role in liver cancer cells through inhibiting tumor suppressor lncRNA, MT1DP in a FoxA1 dependent manner.
      Title: Tumor suppressor long non-coding RNA, MT1DP is negatively regulated by YAP and Runx2 to inhibit FoxA1 in liver cancer cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Other Names

    • metallothionein 1A pseudogene
    • metallothionein 1D, pseudogene (functional)
    • metallothionein M

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to cadmium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to copper ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to zinc ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detoxification of copper ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_003658.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC026461, BG181336

    2. NR_027781.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs at the 5' end and is shorter compared to variant 1.
      Source sequence(s)
      AF348999, BC130317, BG181336
      Related
      ENST00000463480.7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      56643687..56644941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      62438667..62439921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175620.1: Suppressed sequence

      Description
      NM_175620.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1L3X4.1 GenPept UniProtKB/Swiss-Prot:A1L3X4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials
    Miscellaneous