SLC5A10 solute carrier family 5 member 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC5A10provided by HGNC
Official Full Name: solute carrier family 5 member 10provided by HGNC
Primary source: HGNC:HGNC:23155
See related: Ensembl:ENSG00000154025 MIM:618636; AllianceGenome:HGNC:23155
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SGLT5; SGLT-5
Summary: This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed in the kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Expression: Biased expression in kidney (RPKM 27.8), skin (RPKM 6.0) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 17p11.2

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (18950676..19022565)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (18897202..18970458)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (18853989..18925878)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SGLT5 is the renal transporter for 1,5-anhydroglucitol, a major player in two rare forms of neutropenia.
Title: SGLT5 is the renal transporter for 1,5-anhydroglucitol, a major player in two rare forms of neutropenia.
Rare variants in SLC5A10 are associated with serum 1,5-anhydroglucitol (1,5-AG) in the Atherosclerosis Risk in Communities (ARIC) Study.
Title: Rare variants in SLC5A10 are associated with serum 1,5-anhydroglucitol (1,5-AG) in the Atherosclerosis Risk in Communities (ARIC) Study.
Results show that rs2257609 C>T is located in the intron region of SLC5A10 and is significantly associated with worse overall and disease-free survival of non-small-cell lung cancer (NSCLC) patients. The rs2257609 C>T variant does not affect the expression of SLC5A10 mRNA, but alters the mRNA expression and promoter activity of DRG2.
Title: Functional intronic variant of SLC5A10 affects DRG2 expression and survival outcomes of early-stage non-small-cell lung cancer.
hSGLT5 is a sodium/mannose transporter that is blocked by phlorizin. Li(+) and H(+) ions were also able to drive mannose transport, and transport was electrogenic.
Title: Fingerprints of hSGLT5 sugar and cation selectivity.
SGLT-5 as a kidney mannose transporter
Title: Functional characterisation of human SGLT-5 as a novel kidney-specific sodium-dependent sugar transporter.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17S29 (e-PCR)
- UniSTS:147214

WI-14642 (e-PCR)
- UniSTS:80241

D17S29 (e-PCR)
- UniSTS:146825

GRAP_9174 (e-PCR)
- UniSTS:471453

D17S737 (e-PCR)
- UniSTS:147141

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables fructose:sodium symporter activity	IEA Inferred from Electronic Annotation more info
enables glucose:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables mannose:sodium symporter activity	IEA Inferred from Electronic Annotation more info
enables solute:sodium symporter activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in fructose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in glucose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in hexose transmembrane transport	TAS Traceable Author Statement more info
involved_in mannose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: sodium/mannose cotransporter SLC5A10

Names: Na(+)/glucose cotransporter 5; sodium/glucose cotransporter 5; solute carrier family 5 (sodium/glucose cotransporter), member 10; solute carrier family 5 (sodium/sugar cotransporter), member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042450.4 → NP_001035915.1 sodium/mannose cotransporter SLC5A10 isoform 2

See identical proteins and their annotated locations for NP_001035915.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AA745934, AC003957, BC034380, BP332461, DR003789

Consensus CDS

CCDS42275.1

UniProtKB/Swiss-Prot

A0PJK1, A8MUC9, B4DPI0, B7WPR4, Q6P5X0, Q8IXM4, Q96LQ1

Related

ENSP00000379007.3, ENST00000395645.4

Conserved Domains (1) summary

cd11489
Location:17 → 596

SLC5sbd_SGLT5; Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain
NM_001270648.3 → NP_001257577.1 sodium/mannose cotransporter SLC5A10 isoform 3

See identical proteins and their annotated locations for NP_001257577.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AA745934, AC003957, BC062617, BP332461

Consensus CDS

CCDS59278.1

UniProtKB/Swiss-Prot

A0PJK1

Related

ENSP00000379005.2, ENST00000395643.6

Conserved Domains (1) summary

cl00456
Location:17 → 569

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
NM_001270649.2 → NP_001257578.1 sodium/mannose cotransporter SLC5A10 isoform 4

See identical proteins and their annotated locations for NP_001257578.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.

Source sequence(s)

AA745934, AC003957, AK298345, BC062617, BP332461, DR003789

Consensus CDS

CCDS59277.1

UniProtKB/Swiss-Prot

A0PJK1

Related

ENSP00000401875.2, ENST00000417251.6

Conserved Domains (1) summary

cl00456
Location:17 → 560

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
NM_001282417.1 → NP_001269346.1 sodium/mannose cotransporter SLC5A10 isoform 5

See identical proteins and their annotated locations for NP_001269346.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and has many differences in the coding region but maintains the reading frame compared to variant 1. This variant encodes isoform 5, which has a shorter N-terminus and is shorter compared to isoform 1.

Source sequence(s)

AA745934, BC034380, BC039868

Consensus CDS

CCDS74008.1

UniProtKB/Swiss-Prot

A0PJK1

Related

ENSP00000324346.6, ENST00000317977.10

Conserved Domains (1) summary

cl00456
Location:1 → 566

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
NM_152351.6 → NP_689564.3 sodium/mannose cotransporter SLC5A10 isoform 1

See identical proteins and their annotated locations for NP_689564.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AA745934, AC003957, AK057946, BC034380

Consensus CDS

CCDS11201.2

UniProtKB/Swiss-Prot

A0PJK1

Related

ENSP00000379008.2, ENST00000395647.6

Conserved Domains (1) summary

cd11489
Location:17 → 612

SLC5sbd_SGLT5; Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

18950676..19022565

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017024191.3 → XP_016879680.2 sodium/mannose cotransporter SLC5A10 isoform X1

Conserved Domains (1) summary

cl00456
Location:17 → 649

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain