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    sp3 spermathreecae [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42545, updated on 10-May-2024

    Summary

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    Official Symbol
    sp3provided by FlyBase
    Official Full Name
    spermathreecaeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038890
    Locus tag
    Dmel_CG7956
    See related
    AllianceGenome:FB:FBgn0038890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7956; Dmel\CG7956; INPP5F
    Summary
    Predicted to enable phosphatidylinositol-4-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation and regulation of endocytic recycling. Predicted to be active in clathrin-coated endocytic vesicle and early endosome. Is expressed in adult head. Orthologous to human INPP5F (inositol polyphosphate-5-phosphatase F). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See sp3 in Genome Data Viewer
    Location:
    93E4-93E4; 3-72 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21520928..21528598)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17346650..17354320)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44032 Neighboring gene C15 Neighboring gene long non-coding RNA:CR43372 Neighboring gene long non-coding RNA:CR44033

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reproductive consequences of an extra long-term sperm storage organ. Dhillon A, et al. BMC Evol Biol, 2020 Nov 30. PMID 33256600, Free PMC Article
    2. A high-resolution whole-genome map of key chromatin modifications in the adult Drosophila melanogaster. Yin H, et al. PLoS Genet, 2011 Dec. PMID 22194694, Free PMC Article
    3. Differential efficacy of genetically swapping GAL4. Chen YJ, et al. J Neurogenet, 2019 Mar-Jun. PMID 30939963
    4. Genome-wide analysis of Polycomb targets in Drosophila melanogaster. Schwartz YB, et al. Nat Genet, 2006 Jun. PMID 16732288
    5. The exon junction complex differentially marks spliced junctions. Saulière J, et al. Nat Struct Mol Biol, 2010 Oct. PMID 20818392

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of spermathecum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in clathrin-coated endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    spermathreecae
    Names
    CG7956-PA
    CG7956-PD
    CG7956-PE
    CG7956-PF
    CG7956-PG
    sp3-PA
    sp3-PD
    sp3-PE
    sp3-PF
    sp3-PG
    NP_001014644.3
    NP_001036740.2
    NP_001163675.1
    NP_001163676.1
    NP_650972.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21520928..21528598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170204.2 → NP_001163675.1  spermathreecae, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163675.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIS1, Q8MRH8
      Conserved Domains (3) summary
      COG5329
      Location:197 → 565
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam02383
      Location:174 → 413
      Syja_N; SacI homology domain
      pfam12456
      Location:591 → 696
      hSac2; Inositol phosphatase

    2. NM_001170205.2 → NP_001163676.1  spermathreecae, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163676.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIS2
      Conserved Domains (2) summary
      COG5329
      Location:197 → 586
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam02383
      Location:174 → 413
      Syja_N; SacI homology domain

    3. NM_001043275.2 → NP_001036740.2  spermathreecae, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036740.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI33, Q8MRH8
      Conserved Domains (3) summary
      COG5329
      Location:197 → 586
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam02383
      Location:174 → 413
      Syja_N; SacI homology domain
      pfam12456
      Location:663 → 768
      hSac2; Inositol phosphatase

    4. NM_001014644.3 → NP_001014644.3  spermathreecae, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014644.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59DV6, Q8MRH8
      Conserved Domains (3) summary
      COG5329
      Location:197 → 565
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam02383
      Location:174 → 413
      Syja_N; SacI homology domain
      pfam12456
      Location:591 → 696
      hSac2; Inositol phosphatase

    5. NM_142715.3 → NP_650972.2  spermathreecae, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650972.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRH8, Q9VD98
      Conserved Domains (3) summary
      COG5329
      Location:197 → 565
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam02383
      Location:174 → 413
      Syja_N; SacI homology domain
      pfam12456
      Location:591 → 696
      hSac2; Inositol phosphatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JIS1 E1JIS1
    E1JIS2 E1JIS2
    Q0KI33 Q0KI33
    Q59DV6 Q59DV6
    Q8MRH8 Q8MRH8
    Q9VD98 Q9VD98

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