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    COX4 Cytochrome c oxidase subunit 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35279, updated on 10-May-2024

    Summary

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    Official Symbol
    COX4provided by FlyBase
    Official Full Name
    Cytochrome c oxidase subunit 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0032833
    Locus tag
    Dmel_CG10664
    See related
    AllianceGenome:FB:FBgn0032833
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    C-IV s.4; CcO IV; CG10664; CoIV; COX; COX IV; cox4; Cox4; CoxIV; COXIV; CX41; CX42; dCOX-IV; dCOXIV; Dmel\CG10664; IV
    Summary
    Predicted to enable cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrial crista. Is expressed in several structures, including anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval muscle system; and germ layer. Used to study cytochrome-c oxidase deficiency disease. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX4I1 (cytochrome c oxidase subunit 4I1) and COX4I2 (cytochrome c oxidase subunit 4I2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See COX4 in Genome Data Viewer
    Location:
    38A8-38A8; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19958713..19960065)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19958713..19960065)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene sickie Neighboring gene long non-coding RNA:CR43827 Neighboring gene long non-coding RNA:CR45183 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. COX4-like, a Nuclear-Encoded Mitochondrial Gene Duplicate, Is Essential for Male Fertility in Drosophila melanogaster. Eslamieh M, et al. Genes (Basel), 2022 Feb 25. PMID 35327978, Free PMC Article
    2. Decrease in cytochrome c oxidase reserve capacity diminishes robustness of Drosophila melanogaster and shortens lifespan. Klichko V, et al. Biochem J, 2014 Apr 1. PMID 24444354
    3. Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster. Ren JC, et al. Biochem Biophys Res Commun, 2010 Oct 8. PMID 20833144, Free PMC Article
    4. Coordinated organization of mitochondrial lamellar cristae and gain of COX function during mitochondrial maturation in Drosophila. Jiang YF, et al. Mol Biol Cell, 2020 Jan 1. PMID 31746672, Free PMC Article
    5. Lamin Mutations Accelerate Aging via Defective Export of Mitochondrial mRNAs through Nuclear Envelope Budding. Li Y, et al. Curr Biol, 2016 Aug 8. PMID 27451905, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial crista IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of mitochondrial respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial respiratory chain complex IV ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 4
    Names
    CG10664-PA
    CG10664-PB
    CG10664-PC
    CG10664-PD
    COX4-PA
    COX4-PB
    COX4-PC
    COX4-PD
    cytochrome c oxidase
    cytochrome c oxidase IV
    cytochrome c oxidase polypeptide IV
    cytochrome c oxidase subunit IV
    subunit IV

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19958713..19960065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206010.3 → NP_995732.1  cytochrome c oxidase subunit 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995732.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIQ8
      Conserved Domains (1) summary
      pfam02936
      Location:50 → 181
      COX4; Cytochrome c oxidase subunit IV

    2. NM_136169.4 → NP_610013.1  cytochrome c oxidase subunit 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610013.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIQ8
      Related
      FBpp0080835
      Conserved Domains (1) summary
      pfam02936
      Location:50 → 181
      COX4; Cytochrome c oxidase subunit IV

    3. NM_001273683.1 → NP_001260612.1  cytochrome c oxidase subunit 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260612.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIQ8
      Conserved Domains (1) summary
      pfam02936
      Location:50 → 181
      COX4; Cytochrome c oxidase subunit IV

    4. NM_001273684.1 → NP_001260613.1  cytochrome c oxidase subunit 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260613.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIQ8
      Conserved Domains (1) summary
      pfam02936
      Location:50 → 181
      COX4; Cytochrome c oxidase subunit IV
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIQ8 Q9VIQ8

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