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    Kdm2 Lysine demethylase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41090, updated on 10-May-2024

    Summary

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    Official Symbol
    Kdm2provided by FlyBase
    Official Full Name
    Lysine demethylase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0037659
    Locus tag
    Dmel_CG11033
    See related
    AllianceGenome:FB:FBgn0037659
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11033; dkdm2; dKdm2; dKDM2; Dmel\CG11033; dRAF1; FBXL19; JHDM1; kdm2; KDM2
    Summary
    Enables histone H3-tri/di/monomethyl-lysine-4 demethylase activity. Involved in several processes, including histone modification; larval somatic muscle development; and negative regulation of histone modification. Located in nucleus. Part of PcG protein complex. Is expressed in several structures, including adult pars intercerebralis; embryonic/larval digestive system; peritracheal cell; spermatozoon; and ventral group vA neuron. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to several human genes including KDM2B (lysine demethylase 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Kdm2 in Genome Data Viewer
    Location:
    85C3-85C4; 3-48 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9052495..9063245)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4878217..4888967)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene NAD-dependent methylenetetrahydrofolate dehydrogenase Neighboring gene Mst85C Neighboring gene Relish Neighboring gene beag Neighboring gene Adenosine deaminase Neighboring gene pumilio Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KDM2 Family Members are Regulated by HIF-1 in Hypoxia. Batie M, et al. Cells, 2017 Mar 17. PMID 28304334, Free PMC Article
    2. JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta. Clissold PM, et al. Trends Biochem Sci, 2001 Jan. PMID 11165500
    3. The Histone Deacetylase Gene Rpd3 Is Required for Starvation Stress Resistance. Nakajima E, et al. PLoS One, 2016. PMID 27907135, Free PMC Article
    4. Nmdmc overexpression extends Drosophila lifespan and reduces levels of mitochondrial reactive oxygen species. Yu S, et al. Biochem Biophys Res Commun, 2015 Oct 2. PMID 26319556
    5. Drosophila KDM2 is a H3K4me3 demethylase regulating nucleolar organization. Kavi HH, et al. BMC Res Notes, 2009 Oct 23. PMID 19852816, Free PMC Article

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K36 demethylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone H3K4me/H3K4me2/H3K4me3 demethylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
    Inferred from Sequence Model
    more info
    		  
    involved_in larval somatic muscle development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in larval somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in segment specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of PcG protein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lysine demethylase 2
    Names
    CG11033-PB
    CG11033-PC
    CG11033-PD
    CG11033-PE
    JmjC domain-containing histone demethylase 1
    Kdm2-PB
    Kdm2-PC
    Kdm2-PD
    Kdm2-PE
    dRING-associated factor 1
    lysine (K)-specific demethylase 2
    NP_001262400.1
    NP_001262401.1
    NP_001262402.1
    NP_649864.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9052495..9063245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141607.3 → NP_649864.2  lysine demethylase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649864.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YU79, Q9VHH9
      UniProtKB/TrEMBL
      A0A0B4KFJ7, V5P0A0
      Conserved Domains (7) summary
      cd09293
      Location:1166 → 1320
      AMN1; Antagonist of mitotic exit network protein 1
      pfam02008
      Location:670 → 716
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:1126 → 1149
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:1073 → 1108
      F-box-like; F-box-like
      pfam16866
      Location:721 → 801
      PHD_4; PHD-finger
      cl00309
      Location:394 → 467
      PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain
      cl21464
      Location:231 → 331
      cupin_like; Conserved domain found in cupin and related proteins

    2. NM_001275471.1 → NP_001262400.1  lysine demethylase 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262400.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YU79, Q9VHH9
      UniProtKB/TrEMBL
      A0A0B4KFJ7, V5P0A0
      Conserved Domains (7) summary
      cd09293
      Location:1166 → 1320
      AMN1; Antagonist of mitotic exit network protein 1
      pfam02008
      Location:670 → 716
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:1126 → 1149
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:1073 → 1108
      F-box-like; F-box-like
      pfam16866
      Location:721 → 801
      PHD_4; PHD-finger
      cl00309
      Location:394 → 467
      PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain
      cl21464
      Location:231 → 331
      cupin_like; Conserved domain found in cupin and related proteins

    3. NM_001275473.1 → NP_001262402.1  lysine demethylase 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262402.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YU79, Q9VHH9
      UniProtKB/TrEMBL
      A0A0B4KFJ7, V5P0A0
      Conserved Domains (7) summary
      cd09293
      Location:1166 → 1320
      AMN1; Antagonist of mitotic exit network protein 1
      pfam02008
      Location:670 → 716
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:1126 → 1149
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:1073 → 1108
      F-box-like; F-box-like
      pfam16866
      Location:721 → 801
      PHD_4; PHD-finger
      cl00309
      Location:394 → 467
      PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain
      cl21464
      Location:231 → 331
      cupin_like; Conserved domain found in cupin and related proteins

    4. NM_001275472.1 → NP_001262401.1  lysine demethylase 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262401.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YU79, Q9VHH9
      UniProtKB/TrEMBL
      A0A0B4KFJ7, V5P0A0
      Conserved Domains (7) summary
      cd09293
      Location:1166 → 1320
      AMN1; Antagonist of mitotic exit network protein 1
      pfam02008
      Location:670 → 716
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:1126 → 1149
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:1073 → 1108
      F-box-like; F-box-like
      pfam16866
      Location:721 → 801
      PHD_4; PHD-finger
      cl00309
      Location:394 → 467
      PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain
      cl21464
      Location:231 → 331
      cupin_like; Conserved domain found in cupin and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFJ7 A0A0B4KFJ7
    Q9VHH9.2 Q9VHH9

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