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    Cortactin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42491, updated on 10-May-2024

    Summary

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    Official Symbol
    Cortactinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025865
    Locus tag
    Dmel_CG3637
    See related
    AllianceGenome:FB:FBgn0025865
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3637; cortactin; cttn; Dmel\CG3637
    Summary
    Enables proline-rich region binding activity. Involved in oogenesis; positive regulation of cellular component organization; and protein localization to actin cytoskeleton. Located in actin cap; lamellipodium; and plasma membrane. Part of sperm individualization complex. Is expressed in several structures, including anterior endoderm anlage; epithelium; extended germ band embryo; germ layer; and gut section. Orthologous to several human genes including CTTN (cortactin). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Cortactin in Genome Data Viewer
    Location:
    93B8-93B9; 3-70 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21061680..21064471, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16887402..16890193, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Juvenile hormone binding protein 15 Neighboring gene Malvolio Neighboring gene Annexin B9 Neighboring gene rudimentary-like Neighboring gene doublesex-Mab related 93B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genomic organization, transcription start sites, and chromosomal location of the Drosophila cortactin gene. Katsube T, et al. Genes Genet Syst, 2001 Apr. PMID 11434460
    2. The Drosophila protein, Nausicaa, regulates lamellipodial actin dynamics in a Cortactin-dependent manner. O'Connell ME, et al. Biol Open, 2019 Jun 17. PMID 31164339, Free PMC Article
    3. Wear and tear of the intestinal visceral musculature by intrinsic and extrinsic factors. Kim HD, et al. Dev Dyn, 2022 Aug. PMID 35355366, Free PMC Article
    4. Diverse functions of myosin VI in spermiogenesis. Zakrzewski P, et al. Histochem Cell Biol, 2021 Mar. PMID 33386429, Free PMC Article
    5. Myosin VI regulates actin structure specialization through conserved cargo-binding domain sites. Isaji M, et al. PLoS One, 2011. PMID 21853045, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proline-rich region binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in female germline ring canal formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of receptor-mediated endocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cap IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in site of polarized growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm individualization complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cortactin
    Names
    CG3637-PA
    CG3637-PB
    CG3637-PC
    CG3637-PD
    Cortactin-PA
    Cortactin-PB
    Cortactin-PC
    Cortactin-PD
    DCortactin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21061680..21064471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260295.1 → NP_001247224.1  cortactin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247224.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96046, Q9VDF4
      Conserved Domains (3) summary
      cd11959
      Location:502 → 554
      SH3_Cortactin; Src homology 3 domain of Cortactin
      PRK10811
      Location:327 → 489
      rne; ribonuclease E; Reviewed
      pfam02218
      Location:158 → 193
      HS1_rep; Repeat in HS1/Cortactin

    2. NM_001260294.1 → NP_001247223.1  cortactin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247223.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96046, Q9VDF4
      Conserved Domains (3) summary
      cd11959
      Location:502 → 554
      SH3_Cortactin; Src homology 3 domain of Cortactin
      PRK10811
      Location:327 → 489
      rne; ribonuclease E; Reviewed
      pfam02218
      Location:158 → 193
      HS1_rep; Repeat in HS1/Cortactin

    3. NM_079702.3 → NP_524426.2  cortactin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524426.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96046, Q9VDF4
      Related
      FBpp0083441
      Conserved Domains (3) summary
      cd11959
      Location:502 → 554
      SH3_Cortactin; Src homology 3 domain of Cortactin
      PRK10811
      Location:327 → 489
      rne; ribonuclease E; Reviewed
      pfam02218
      Location:158 → 193
      HS1_rep; Repeat in HS1/Cortactin

    4. NM_001260293.2 → NP_001247222.1  cortactin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247222.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96046, Q9VDF4
      Conserved Domains (3) summary
      cd11959
      Location:502 → 554
      SH3_Cortactin; Src homology 3 domain of Cortactin
      PRK10811
      Location:327 → 489
      rne; ribonuclease E; Reviewed
      pfam02218
      Location:158 → 193
      HS1_rep; Repeat in HS1/Cortactin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O96046 O96046
    Q9VDF4 Q9VDF4

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