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    Hibch 3-hydroxyisobutyryl-CoA hydrolase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41869, updated on 10-May-2024

    Summary

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    Official Symbol
    Hibchprovided by FlyBase
    Official Full Name
    3-hydroxyisobutyryl-CoA hydrolaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038326
    Locus tag
    Dmel_CG5044
    See related
    AllianceGenome:FB:FBgn0038326
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5044; CT16187; Dmel\CG5044; HIBCH
    Summary
    Predicted to enable 3-hydroxyisobutyryl-CoA hydrolase activity. Involved in negative regulation of response to wounding. Predicted to be active in mitochondrion. Is expressed in several structures, including dorsal pharyngeal muscle cell; early extended germ band embryo; embryonic Malpighian tubule; embryonic/larval midgut; and presumptive embryonic/larval digestive system. Orthologous to human HIBCH (3-hydroxyisobutyryl-CoA hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Hibch in Genome Data Viewer
    Location:
    88F1-88F1; 3-57 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15357229..15359263)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11182951..11184985)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TRAPP subunit 33 Neighboring gene Transmembrane O-mannosyltransferase targeting cadherins 4 Neighboring gene Autophagy-related 4b Neighboring gene Component of oligomeric golgi complex 2 Neighboring gene Translin associated factor X Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo. Llavero Hurtado M, et al. Sci Rep, 2017 Sep 29. PMID 28963550, Free PMC Article
    2. Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo. Wishart TM, et al. PLoS Genet, 2012. PMID 22952455, Free PMC Article
    3. The loss of Drosophila APG4/AUT2 function modifies the phenotypes of cut and Notch signaling pathway mutants. Thumm M, et al. Mol Genet Genomics, 2001 Dec. PMID 11810238
    4. Metabolic pathways modulate the neuronal toxicity associated with fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Hum Mol Genet, 2019 Mar 15. PMID 30476102, Free PMC Article
    5. An endogenous small interfering RNA pathway in Drosophila. Czech B, et al. Nature, 2008 Jun 5. PMID 18463631, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3-hydroxyisobutyryl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-hydroxyisobutyryl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in valine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    3-hydroxyisobutyryl-CoA hydrolase
    Names
    CG5044-PA
    CG5044-PB
    Hibch-PA
    Hibch-PB
    NP_650453.3
    NP_732020.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15357229..15359263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169649.2 → NP_732020.2  3-hydroxyisobutyryl-CoA hydrolase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732020.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BP1
      Related
      FBpp0082547
      Conserved Domains (2) summary
      PRK05617
      Location:44 → 376
      PRK05617; 3-hydroxyisobutyryl-CoA hydrolase; Provisional
      pfam16113
      Location:56 → 374
      ECH_2; Enoyl-CoA hydratase/isomerase

    2. NM_142196.3 → NP_650453.3  3-hydroxyisobutyryl-CoA hydrolase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650453.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960K8, Q9VF79
      Related
      FBpp0082546
      Conserved Domains (2) summary
      PRK05617
      Location:43 → 375
      PRK05617; 3-hydroxyisobutyryl-CoA hydrolase; Provisional
      pfam16113
      Location:55 → 373
      ECH_2; Enoyl-CoA hydratase/isomerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86BP1 Q86BP1
    Q960K8 Q960K8

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