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    GNBP3 Gram-negative bacteria binding protein 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39020, updated on 19-Jun-2024

    Summary

    Official Symbol
    GNBP3provided by FlyBase
    Official Full Name
    Gram-negative bacteria binding protein 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0040321
    Locus tag
    Dmel_CG5008
    See related
    AllianceGenome:FB:FBgn0040321
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5008; DGNBP-3; Dmel\CG5008; GNBP; GNBP-3; gnbp3; Gnbp3; Hades
    Summary
    Enables (1->3)-beta-D-glucan binding activity and lipopolysaccharide binding activity. Involved in positive regulation of Toll signaling pathway; positive regulation of melanization defense response; and response to fungus. Located in cell surface. Is expressed in adult head; embryonic/larval apodeme; and embryonic/larval epidermis. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    See GNBP3 in Genome Data Viewer
    Location:
    66E5-66E5; 3-27 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8955021..8956551)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8948121..8949651)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43970 Neighboring gene Tetraspanin 66E Neighboring gene uncharacterized protein Neighboring gene orb2 Neighboring gene mitochondrial ribosomal protein L12 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables (1->3)-beta-D-glucan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables beta-glucanase activity IKR
    Inferred from Key Residues
    more info
    PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables hydrolase activity IKR
    Inferred from Key Residues
    more info
    PubMed 
    enables lipopolysaccharide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pattern recognition receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Gram-negative bacteria binding protein 3
    Names
    CG5008-PA
    GNBP-3
    GNBP3-PA
    Gram-negative binding protein 3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8955021..8956551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079262.3NP_523986.2  Gram-negative bacteria binding protein 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523986.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0ZX55, A0ZX56, A0ZX59, A0ZX64, Q9NHA8, Q9VSR4
      UniProtKB/TrEMBL
      B5X538
      Related
      FBpp0076237
      Conserved Domains (2) summary
      cd02179
      Location:175489
      GH16_beta_GRP; beta-1,3-glucan recognition protein, member of glycosyl hydrolase family 16
      pfam15886
      Location:27132
      CBM39; Carbohydrate binding domain (family 32)