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    Mo25 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39858, updated on 10-May-2024

    Summary

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    Official Symbol
    Mo25provided by FlyBase
    Primary source
    FLYBASE:FBgn0017572
    Locus tag
    Dmel_CG4083
    See related
    AllianceGenome:FB:FBgn0017572
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4083; Dmel\CG4083; DmMo25; dMo25; Dmo25; l(3)00274; mo25
    Summary
    Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in intracellular signal transduction. Located in cytoplasm and nucleus. Is expressed in several structures, including adult head; embryonic Malpighian tubule; embryonic/larval midgut; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CAB39 (calcium binding protein 39) and CAB39L (calcium binding protein 39 like). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Mo25 in Genome Data Viewer
    Location:
    73B1-73B1; 3-44 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16613218..16615472, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16606318..16608572, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45865 Neighboring gene Suppressor of ref(2)P sterility Neighboring gene uncharacterized protein Neighboring gene Abl tyrosine kinase Neighboring gene baldspot Neighboring gene small nuclear RNA U12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of the Drosophila Mo25 gene, which is conserved among Drosophila, mouse, and yeast. Nozaki M, et al. DNA Cell Biol, 1996 Jun. PMID 8672247
    2. Intracellular Chloride and Scaffold Protein Mo25 Cooperatively Regulate Transepithelial Ion Transport through WNK Signaling in the Malpighian Tubule. Sun Q, et al. J Am Soc Nephrol, 2018 May. PMID 29602832, Free PMC Article
    3. Phosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation and Organ Growth by Decreased Activation of AMPK. Borkowsky S, et al. Cells, 2023 Mar 6. PMID 36899949, Free PMC Article
    4. Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression. Dogliotti G, et al. Nat Commun, 2017 Jun 26. PMID 28649994, Free PMC Article
    5. The GC kinase Fray and Mo25 regulate Drosophila asymmetric divisions. Yamamoto Y, et al. Biochem Biophys Res Commun, 2008 Feb 1. PMID 18054329

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mo25
    Names
    CG4083-PA
    CG4083-PB
    Mo25-PA
    Mo25-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16613218..16615472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079393.2 → NP_524117.1  Mo25, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524117.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91891, Q540S2, Q9VV85
      UniProtKB/TrEMBL
      M9PI82
      Related
      FBpp0075117, FBtr0075358
      Conserved Domains (1) summary
      pfam08569
      Location:3 → 334
      Mo25; Mo25-like

    2. NM_001275029.1 → NP_001261958.1  Mo25, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261958.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91891, Q540S2, Q9VV85
      UniProtKB/TrEMBL
      M9PI82
      Conserved Domains (1) summary
      pfam08569
      Location:3 → 334
      Mo25; Mo25-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PI82 M9PI82
    P91891.2 P91891

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