Nrarp Notch-regulated ankyrin repeat protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nrarpprovided by MGI
Official Full Name: Notch-regulated ankyrin repeat proteinprovided by MGI
Primary source: MGI:MGI:1914372
See related: Ensembl:ENSMUSG00000078202 AllianceGenome:MGI:1914372
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2700054M22Rik
Summary: Acts upstream of or within several processes, including angiogenesis; negative regulation of Notch signaling pathway involved in somitogenesis; and somite rostral/caudal axis specification. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; paraxial mesenchyme; and retina. Orthologous to human NRARP (NOTCH regulated ankyrin repeat protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 17.05 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (25070770..25073351)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (25180758..25183339)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-487b-3p negatively regulates osteogenesis by suppressing Nrarp expression, which in turn, suppresses Runx-2 and Wnt signaling, both of which play a pivotal action in osteoblast differentiation
Title: miR-487b-3p impairs osteoblastogenesis by targeting Notch-regulated ankyrin-repeat protein (Nrarp).
The transcription and expression patterns of Notch pathway components (Notch 1-3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated in the mouse testis
Title: Dynamics of Notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle.
Nrarp is essential for forming the proper number and morphology of axial skeleton components
Title: The period of the somite segmentation clock is sensitive to Notch activity.
Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate.
Title: Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate.
Results show that the Notch-regulated ankyrin repeat protein (Nrarp) acts as a molecular link between Notch- and Lef1-dependent Wnt signaling in endothelial cells to control stability of new vessel connections in mouse and zebrafish.
Title: Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis.
Different effects of Nrarp overexpression suggest that alternate Notch signaling pathways mediate T- versus B-cell lineage commitment and thymocyte maturation.
Title: Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development.
please add ref to Xenopus: 2002 Mechanisms of Development 110, 113-124. Where they call it "Xnap"
Title: XNAP, a conserved ankyrin repeat-containing protein with a role in the Notch pathway during Xenopus primary neurogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

UniSTS:498750 (e-PCR)
- UniSTS:498750

Nrarp (e-PCR), detects polymorphism
- UniSTS:498750

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching involved in blood vessel morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of vascular endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within somite rostral/caudal axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of vascular endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vascular endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: notch-regulated ankyrin repeat-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025980.2 → NP_080256.2 notch-regulated ankyrin repeat-containing protein

See identical proteins and their annotated locations for NP_080256.2

Status: VALIDATED

Source sequence(s)

AY046077

Consensus CDS

CCDS38066.1

UniProtKB/Swiss-Prot

Q80UV7, Q91ZA8, Q9CZM1

Related

ENSMUSP00000100615.3, ENSMUST00000104999.4

Conserved Domains (2) summary

sd00045
Location:50 → 81

ANK; ANK repeat [structural motif]

pfam12796
Location:21 → 106

Ank_2; Ankyrin repeats (3 copies)