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    ampD N-acetyl-anhydromuranmyl-L-alanine amidase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 881105, updated on 24-Sep-2023

    Summary

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    Gene symbol
    ampD
    Gene description
    N-acetyl-anhydromuranmyl-L-alanine amidase
    Locus tag
    PA4522
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (5064774..5065340, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene ornithine decarboxylase Neighboring gene chemotaxis transducer Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene nicotinate-nucleotide pyrophosphorylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Elucidation of Mechanisms of Ceftazidime Resistance among Clinical Isolates of Pseudomonas aeruginosa by Using Genomic Data. Kos VN, et al. Antimicrob Agents Chemother, 2016 Jun. PMID 27067331, Free PMC Article
    2. NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa. Zamorano L, et al. Antimicrob Agents Chemother, 2010 Sep. PMID 20566764, Free PMC Article
    3. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    4. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
    5. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Changes have been identified within AmpD responsible for derepression of ampC and conferring ceftazidime resistance.
      Title: Elucidation of Mechanisms of Ceftazidime Resistance among Clinical Isolates of Pseudomonas aeruginosa by Using Genomic Data.
    2. NagZ restored the wild-type beta-lactam MICs and ampC expression of PAO1 dacB and ampD mutants and dramatically reduced the MICs and the level of ampC expression in the dacB-ampD double mutant.
      Title: NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables N-acetylmuramoyl-L-alanine amidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of beta-lactamase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Gram-negative-bacterium-type cell wall IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-acetyl-anhydromuranmyl-L-alanine amidase
    NP_253212.1
    • Product name confidence: class 2 (High similarity to functionally studied protein)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5064774..5065340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_253212.1 N-acetyl-anhydromuranmyl-L-alanine amidase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_253212.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      G3XCW9, Q9ZGA0
      Conserved Domains (1) summary
      PRK11789
      Location:1 → 186
      PRK11789; 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD
    Nucleotide Protein
    Heading Accession and Version

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