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    CDC55 protein phosphatase 2A regulatory subunit CDC55 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852685, updated on 25-Apr-2024

    Summary

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    Gene symbol
    CDC55
    Gene description
    protein phosphatase 2A regulatory subunit CDC55
    Primary source
    SGD:S000003158
    Locus tag
    YGL190C
    See related
    AllianceGenome:SGD:S000003158
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    TMR4
    Summary
    Enables protein phosphatase regulator activity. Involved in several processes, including peptidyl-serine dephosphorylation; positive regulation of protein localization; and regulation of mitotic cell cycle phase transition. Located in several cellular components, including cellular bud tip; fungal-type vacuole membrane; and mating projection tip. Part of protein phosphatase type 2A complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease; breast cancer; and spinocerebellar ataxia type 12. Orthologous to several human genes including PPP2R2A (protein phosphatase 2 regulatory subunit Balpha); PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta); and PPP2R2D (protein phosphatase 2 regulatory subunit Bdelta). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (145809..147389, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene mRNA (N6-adenosine)-methyltransferase Neighboring gene cytochrome c oxidase subunit VIa Neighboring gene ribosomal 40S subunit protein S26A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphoproteomic Effects of Acute Depletion of PP2A Regulatory Subunit Cdc55. Plank M, et al. Proteomics, 2021 Jan. PMID 32970932
    2. Identification of a mutation causing a defective spindle assembly checkpoint in high ethyl caproate-producing sake yeast strain K1801. Goshima T, et al. Biosci Biotechnol Biochem, 2016 Aug. PMID 27191586
    3. The role of Cdc55 in the spindle checkpoint is through regulation of mitotic exit in Saccharomyces cerevisiae. Yellman CM, et al. Mol Biol Cell, 2006 Feb. PMID 16314395, Free PMC Article
    4. Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast. Minshull J, et al. Curr Biol, 1996 Dec 1. PMID 8994825
    5. PP2A(Cdc55) Phosphatase Imposes Ordered Cell-Cycle Phosphorylation by Opposing Threonine Phosphorylation. Godfrey M, et al. Mol Cell, 2017 Feb 2. PMID 28132839, Free PMC Article

    See all (146) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein phosphatase 2A (PP2A) promotes anaphase entry after DNA replication stress in budding yeast.
      Title: Protein phosphatase 2A (PP2A) promotes anaphase entry after DNA replication stress in budding yeast.
    2. Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae.
      Title: Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae.
    3. PP2A(Cdc55) dephosphorylates Pds1 and inhibits spindle elongation in S. cerevisiae.
      Title: PP2A(Cdc55) dephosphorylates Pds1 and inhibits spindle elongation in S. cerevisiae.
    4. Cdc14 and PP2A Phosphatases Cooperate to Shape Phosphoproteome Dynamics during Mitotic Exit.
      Title: Cdc14 and PP2A Phosphatases Cooperate to Shape Phosphoproteome Dynamics during Mitotic Exit.
    5. Yeast Sphingolipid Phospholipase Gene ISC1 Regulates the Spindle Checkpoint by a CDC55-Dependent Mechanism.
      Title: Yeast Sphingolipid Phospholipase Gene ISC1 Regulates the Spindle Checkpoint by a CDC55-Dependent Mechanism.
    6. CDC55 role in the regulation pericentric cohesin and anaphase onset.
      Title: Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset.
    7. Cdc55 is required for reductional chromosome segregation during achiasmate meiosis.
      Title: PP2A(Cdc55)'s role in reductional chromosome segregation during achiasmate meiosis in budding yeast is independent of its FEAR function.
    8. Results show that the phosphatase PP2ACdc55 counteracts and thereby delays cell-cycle phosphorylation by cyclin-dependent kinase specifically on threonine, but not serine, phosphorylation sites.
      Title: PP2A(Cdc55) Phosphatase Imposes Ordered Cell-Cycle Phosphorylation by Opposing Threonine Phosphorylation.
    9. orchestrated action of PP2A antagonizes Atg13 phosphorylation and promotes autophagy after the inactivation of TORC1
      Title: Orchestrated Action of PP2A Antagonizes Atg13 Phosphorylation and Promotes Autophagy after the Inactivation of TORC1.
    10. Constitutively active Pkc1 can drive cells through a mitotic checkpoint arrest, which suggests that Pkc1-dependent activation of PP2A(Cdc55) plays a critical role in checkpoint signaling.
      Title: Protein Kinase C Controls Binding of Igo/ENSA Proteins to Protein Phosphatase 2A in Budding Yeast.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in achiasmate meiosis I IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular hyperosmotic salinity response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homologous chromosome segregation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in microautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic G2/M transition checkpoint IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of autophagosome assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by transcription factor localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein phosphatase type 2A complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein phosphatase type 2A complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein phosphatase 2A regulatory subunit CDC55
    NP_011325.1
    • Regulatory subunit B of protein phosphatase 2A (PP2A); Zds1p/2p-dependent localization to cytoplasm promotes mitotic entry; localization to nucleus prevents mitotic exit; required for correct nuclear division, chromosome segregation during achiasmate meiosis; maintains nucleolar sequestration of Cdc14p in early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion; controls phosphorylation and stability of Cln2p; homolog of mammalian B55

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      145809..147389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181055.1 → NP_011325.1  TPA: protein phosphatase 2A regulatory subunit CDC55 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011325.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTW4, Q00362
      UniProtKB/TrEMBL
      A0A6L0YVT7, A6ZTZ8, B3LHN9, B5VIE4, C8Z861, N1PA03
      Conserved Domains (2) summary
      COG5170
      Location:1 → 526
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:136 → 181
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00362.2

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