Sts steroid sulfatase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stsprovided by RGD
Official Full Name: steroid sulfataseprovided by RGD
Primary source: RGD:3783
See related: Ensembl:ENSRNOG00000032487 AllianceGenome:RGD:3783
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables steryl-sulfatase activity. Involved in several processes, including response to estrogen; response to pH; and response to peptide hormone. Located in endoplasmic reticulum membrane and nuclear envelope. Is integral component of membrane. Biomarker of cryptorchidism and hypertension. Human ortholog(s) of this gene implicated in X-linked ichthyosis. Orthologous to human STS (steroid sulfatase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 60.7), Adrenal (RPKM 59.0) and 9 other tissues See more
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Genomic context

Location:: Xq21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (46102524..46110868)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (42225131..42233403)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (45420418..45428748)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arylsulfatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables steryl-sulfatase activity	IDA Inferred from Direct Assay more info	PubMed
enables sulfuric ester hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in female pregnancy	IEA Inferred from Electronic Annotation more info
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to estrogen	IDA Inferred from Direct Assay more info	PubMed
involved_in response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in response to pH	IDA Inferred from Direct Assay more info	PubMed
involved_in response to peptide hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in skin development	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: steryl-sulfatase

Names: ASC; arylsulfatase C; steroid sulfatase (microsomal), isozyme S; steryl-sulfate sulfohydrolase

NP_036793.2

EC 3.1.6.2

XP_006257023.1

EC 3.1.6.2

XP_006257024.1

EC 3.1.6.2

XP_063135863.1

EC 3.1.6.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012661.2 → NP_036793.2 steryl-sulfatase precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

P15589

UniProtKB/TrEMBL

A6IPT8, G3V9E5

Related

ENSRNOP00000043915.3, ENSRNOT00000051897.5

Conserved Domains (1) summary

cl23718
Location:26 → 548

ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

46102524..46110868

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256961.5 → XP_006257023.1 steryl-sulfatase isoform X1

See identical proteins and their annotated locations for XP_006257023.1

UniProtKB/Swiss-Prot

P15589

UniProtKB/TrEMBL

A6IPT8, G3V9E5

Conserved Domains (1) summary

cl23718
Location:26 → 548

ALP_like; alkaline phosphatases and sulfatases
XM_006256962.5 → XP_006257024.1 steryl-sulfatase isoform X2

UniProtKB/Swiss-Prot

P15589

Conserved Domains (2) summary

COG3119
Location:26 → 415

AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]

cl23718
Location:26 → 441

ALP_like; alkaline phosphatases and sulfatases
XM_063279793.1 → XP_063135863.1 steryl-sulfatase isoform X2